Metal complexes of diisopropylthiourea: synthesis, characterization and antibacterial studies

Int J Mol Sci. 2011;12(10):7186-98. doi: 10.3390/ijms12107186. Epub 2011 Oct 21.

Abstract

Co(II), Cu(II), Zn(II) and Fe(III) complexes of diisopropylthiourea have been synthesized and characterized by elemental analyses, molar conductivity, magnetic susceptibility, FTIR and electronic spectroscopy. The compounds are non-electrolytes in solution and spectroscopic data of the complexes are consistent with 4-coordinate geometry for the metal(II) complexes and six coordinate octahedral for Fe(III) complex. The complexes were screened for their antibacterial activities against six bacteria: Escherichia coli, Pseudomonas auriginosa, Klebsiella pneumoniae, Bacillus cereus, Staphylococcus aureus and Bacillus pumilus. The complexes showed varied antibacterial activities and their minimum inhibitory concentrations (MICs) were determined.

Keywords: antibacterial; diisopropylthiourea; drug resistance; metal complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Coordination Complexes / chemical synthesis*
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Crystallography, X-Ray
  • Drug Resistance, Bacterial / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Metals / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Spectroscopy, Fourier Transform Infrared
  • Thiourea / chemistry*

Substances

  • Anti-Bacterial Agents
  • Coordination Complexes
  • Metals
  • Thiourea