Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs

Bioorg Med Chem. 2015 Mar 15;23(6):1251-9. doi: 10.1016/j.bmc.2015.01.047. Epub 2015 Feb 3.

Abstract

A series of opioid and serotonin re-uptake inhibitors (SSRIs) bifunctional ligands have been designed, synthesized, and tested for their activities and efficacies at μ-, δ- and κ opioid receptors and SSRIs receptors. Most of the compounds showed high affinities for μ- and δ-opioid receptors and lower affinities for SSRIs and κ opioid receptors. A docking study on the μ-opioid receptor binding pocket has been carried out for ligands 3-11. The ligands 7 and 11 have displayed the highest binding profiles for the μ-opioid receptor binding site with ΔGbind (-12.14kcal/mol) and Ki value (1.0nM), and ΔGbind (-12.41kcal/mol) and Ki value (0.4nM), respectively. Ligand 3 was shown to have the potential of dual acting serotonin/norepinephrine re-uptake inhibitor (SNRI) antidepressant activity in addition to opioid activities, and thus could be used for the design of multifunctional ligands in the area of a novel approach for the treatment of pain and depression.

Keywords: Bifunctional ligands; Depression; Opioid; Pain; SSRIs; Synergistic effect.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Dose-Response Relationship, Drug
  • Drug Design*
  • Humans
  • Ligands
  • Molecular Structure
  • Receptors, Opioid / metabolism*
  • Receptors, Serotonin / metabolism*
  • Selective Serotonin Reuptake Inhibitors / chemical synthesis
  • Selective Serotonin Reuptake Inhibitors / chemistry
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Structure-Activity Relationship

Substances

  • Ligands
  • Receptors, Opioid
  • Receptors, Serotonin
  • Serotonin Uptake Inhibitors