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Computationally designed GPCR quaternary structures bias signaling pathway activation.
Paradis JS, Feng X, Murat B, Jefferson RE, Sokrat B, Szpakowska M, Hogue M, Bergkamp ND, Heydenreich FM, Smit MJ, Chevigné A, Bouvier M, Barth P. Paradis JS, et al. Among authors: bergkamp nd. Nat Commun. 2022 Nov 11;13(1):6826. doi: 10.1038/s41467-022-34382-7. Nat Commun. 2022. PMID: 36369272 Free PMC article.
NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET.
van den Bor J, Bergkamp ND, Anbuhl SM, Dekker F, Comez D, Perez Almeria CV, Bosma R, White CW, Kilpatrick LE, Hill SJ, Siderius M, Smit MJ, Heukers R. van den Bor J, et al. Among authors: bergkamp nd. Cell Rep Methods. 2023 Mar 13;3(3):100422. doi: 10.1016/j.crmeth.2023.100422. eCollection 2023 Mar 27. Cell Rep Methods. 2023. PMID: 37056381 Free PMC article.
The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.
van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJP, van Dongen GAMS, Söderberg-Nauclér C, Würdinger T, Siderius M, Smit MJ. van Senten JR, et al. Among authors: bergkamp nd. J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13. J Biol Chem. 2019. PMID: 31519750 Free PMC article.