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The Mammalian Cysteine Protease Legumain in Health and Disease.
Solberg R, Lunde NN, Forbord KM, Okla M, Kassem M, Jafari A. Solberg R, et al. Among authors: lunde nn. Int J Mol Sci. 2022 Dec 15;23(24):15983. doi: 10.3390/ijms232415983. Int J Mol Sci. 2022. PMID: 36555634 Free PMC article. Review.
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial.
Gregersen I, Michelsen AE, Lunde NN, Åkerblom A, Lakic TG, Skjelland M, Ryeng Skagen K, Becker RC, Lindbäck J, Himmelmann A, Solberg R, Johansen HT, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Ueland T, Wallentin L, Halvorsen B. Gregersen I, et al. Among authors: lunde nn. J Am Heart Assoc. 2020 Sep;9(17):e016360. doi: 10.1161/JAHA.120.016360. Epub 2020 Aug 15. J Am Heart Assoc. 2020. PMID: 32809893 Free PMC article. Clinical Trial.
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B. Lunde NN, et al. Atherosclerosis. 2020 Mar;296:74-82. doi: 10.1016/j.atherosclerosis.2019.12.008. Epub 2019 Dec 14. Atherosclerosis. 2020. PMID: 31870625 Free article.