Abstract
Gold(I) N-heterocyclic carbene (NHC) complexes were obtained in good yields from the corresponding silver complexes by treatment with [AuCl(PPh3)] following the commonly used silver carbene transfer route. The silver complexes were synthesized from the benzimidazolium halide salts by the in situ reactions with Ag2O in dichloromethane as a solvent at room temperature. All gold complexes have been characterized by 1H-NMR, 13C-NMR and IR spectroscopy and elemental analysis. Au-NHC complexes were evaluated for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria and fungal species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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Benzimidazoles / chemical synthesis
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Benzimidazoles / chemistry*
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Benzimidazoles / pharmacology
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Candida albicans / drug effects
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Candida tropicalis / drug effects
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Enterococcus faecalis / drug effects
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Escherichia coli / drug effects
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Gold / chemistry*
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Ligands
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Magnetic Resonance Spectroscopy
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Methane / analogs & derivatives*
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Methane / chemistry
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Pseudomonas aeruginosa / drug effects
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Spectrophotometry, Infrared
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Benzimidazoles
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Ligands
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carbene
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Gold
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Methane