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Rise and fall of an anti-MUC1 specific antibody.
Thie H, Toleikis L, Li J, von Wasielewski R, Bastert G, Schirrmann T, Esteves IT, Behrens CK, Fournes B, Fournier N, de Romeuf C, Hust M, Dübel S. Thie H, et al. PLoS One. 2011 Jan 14;6(1):e15921. doi: 10.1371/journal.pone.0015921. PLoS One. 2011. PMID: 21264246 Free PMC article.
The scFv bound to T47D and MCF-7 mammalian cancer cell lines were recloned into the scFv-Fc and IgG format resulting in decrease of affinity of one binder. The IgG variants with the highest affinity were tested in mouse xenograft models using MCF-7 and OVCAR tumour cells. …
The scFv bound to T47D and MCF-7 mammalian cancer cell lines were recloned into the scFv-Fc and IgG format resulting in decrease of affinity …
TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing-remitting multiple sclerosis.
Unterrainer M, Mahler C, Vomacka L, Lindner S, Havla J, Brendel M, Böning G, Ertl-Wagner B, Kümpfel T, Milenkovic VM, Rupprecht R, Kerschensteiner M, Bartenstein P, Albert NL. Unterrainer M, et al. Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1423-1431. doi: 10.1007/s00259-018-3974-7. Epub 2018 Mar 9. Eur J Nucl Med Mol Imaging. 2018. PMID: 29523925
All patients underwent TSPO genotyping and were classified as high-affinity, medium-affinity or low-affinity binders (HAB/MAB/LAB). PET scans were performed after administration of 189 12 MBq [(18)F]GE-180, and 60-90 min summation images were used for visual analysis and a …
All patients underwent TSPO genotyping and were classified as high-affinity, medium-affinity or low-affinity binders (HAB/MAB/LAB). P …