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Page 1
Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention.
Int J Mol Sci. 2022 Apr 27;23(9):4840. doi: 10.3390/ijms23094840.
Int J Mol Sci. 2022.
PMID: 35563228
Free PMC article.
Review.
PI3KC2α inhibition is antithrombotic in blood from hypercholesterolemic mice.
Setiabakti NM, Tarlac V, Larsson P, Hamilton JR.
Setiabakti NM, et al.
J Thromb Haemost. 2024 Jan;22(1):249-254. doi: 10.1016/j.jtha.2023.09.030. Epub 2023 Oct 11.
J Thromb Haemost. 2024.
PMID: 37827379
Item in Clipboard
Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.
Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, Eckly A, Gachet C, Nesbitt WS, Thompson PE, Hamilton JR.
Selvadurai MV, et al. Among authors: setiabakti nm.
Sci Transl Med. 2020 Jul 22;12(553):eaar8430. doi: 10.1126/scitranslmed.aar8430.
Sci Transl Med. 2020.
PMID: 32718993
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The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP.
Mountford JK, et al. Among authors: setiabakti nm.
Nat Commun. 2015 Mar 17;6:6535. doi: 10.1038/ncomms7535.
Nat Commun. 2015.
PMID: 25779105
Free article.
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Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability.
Petitjean C, Setiabakti NM, Mountford JK, Arthur JF, Ellis S, Hamilton JR.
Petitjean C, et al. Among authors: setiabakti nm.
Platelets. 2016 Jul;27(5):402-9. doi: 10.3109/09537104.2016.1145202. Epub 2016 Mar 4.
Platelets. 2016.
PMID: 26943229
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