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2015 1
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Page 1
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity.
Rosás-Umbert M, Gunst JD, Pahus MH, Olesen R, Schleimann M, Denton PW, Ramos V, Ward A, Kinloch NN, Copertino DC, Escribà T, Llano A, Brumme ZL, Brad Jones R, Mothe B, Brander C, Fox J, Nussenzweig MC, Fidler S, Caskey M, Tolstrup M, Søgaard OS. Rosás-Umbert M, et al. Among authors: kinloch nn. Nat Commun. 2022 Oct 29;13(1):6473. doi: 10.1038/s41467-022-34171-2. Nat Commun. 2022. PMID: 36309514 Free PMC article.
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
Gunst JD, Pahus MH, Rosás-Umbert M, Lu IN, Benfield T, Nielsen H, Johansen IS, Mohey R, Østergaard L, Klastrup V, Khan M, Schleimann MH, Olesen R, Støvring H, Denton PW, Kinloch NN, Copertino DC, Ward AR, Alberto WDC, Nielsen SD, Puertas MC, Ramos V, Reeves JD, Petropoulos CJ, Martinez-Picado J, Brumme ZL, Jones RB, Fox J, Tolstrup M, Nussenzweig MC, Caskey M, Fidler S, Søgaard OS. Gunst JD, et al. Among authors: kinloch nn. Nat Med. 2022 Nov;28(11):2424-2435. doi: 10.1038/s41591-022-02023-7. Epub 2022 Oct 17. Nat Med. 2022. PMID: 36253609 Free PMC article. Clinical Trial.
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. mBio. 2023 Nov 16;14(6):e0241723. doi: 10.1128/mbio.02417-23. Online ahead of print. mBio. 2023. PMID: 37971267 Free PMC article.
SARS-CoV-2 RNA Quantification Using Droplet Digital RT-PCR.
Kinloch NN, Ritchie G, Dong W, Cobarrubias KD, Sudderuddin H, Lawson T, Matic N, Montaner JSG, Leung V, Romney MG, Lowe CF, Brumme CJ, Brumme ZL. Kinloch NN, et al. J Mol Diagn. 2021 Aug;23(8):907-919. doi: 10.1016/j.jmoldx.2021.04.014. Epub 2021 May 29. J Mol Diagn. 2021. PMID: 34062285 Free PMC article.
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. bioRxiv [Preprint]. 2023 Apr 13:2023.04.12.536611. doi: 10.1101/2023.04.12.536611. bioRxiv. 2023. PMID: 37090500 Free PMC article. Updated. Preprint.
Novel Acylguanidine-Based Inhibitor of HIV-1.
Mwimanzi P, Tietjen I, Miller SC, Shahid A, Cobarrubias K, Kinloch NN, Baraki B, Richard J, Finzi A, Fedida D, Brumme ZL, Brockman MA. Mwimanzi P, et al. Among authors: kinloch nn. J Virol. 2016 Sep 29;90(20):9495-508. doi: 10.1128/JVI.01107-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27512074 Free PMC article.
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).
Kinloch NN, Ren Y, Conce Alberto WD, Dong W, Khadka P, Huang SH, Mota TM, Wilson A, Shahid A, Kirkby D, Harris M, Kovacs C, Benko E, Ostrowski MA, Del Rio Estrada PM, Wimpelberg A, Cannon C, Hardy WD, MacLaren L, Goldstein H, Brumme CJ, Lee GQ, Lynch RM, Brumme ZL, Jones RB. Kinloch NN, et al. Nat Commun. 2021 Jan 8;12(1):165. doi: 10.1038/s41467-020-20442-3. Nat Commun. 2021. PMID: 33420062 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL; MACS/WIHS combined cohort study (MWCSS). Shahid A, et al. Among authors: kinloch nn. J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214547 Free PMC article.
HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antiretroviral Therapy.
Omondi FH, Sudderuddin H, Shahid A, Kinloch NN, Jones BR, Miller RL, Tsai O, MacMillan D, Trocha A, Brockman MA, Brumme CJ, Joy JB, Liang R, Walker BD, Brumme ZL. Omondi FH, et al. Among authors: kinloch nn. mBio. 2021 Dec 21;12(6):e0249021. doi: 10.1128/mBio.02490-21. Epub 2021 Nov 16. mBio. 2021. PMID: 34781741 Free PMC article.
27 results