Diffuse large B-cell lymphoma of the gallbladder arised 8 years after malignant lymphoma of the right testis: A case report and literature review

Kengo Kai; Takeomi Hamada; Masahide Hiyoshi; Naoya Imamura; Koichi Yano; Motoaki Nagano; Masahiro Kai; Tomonori Hidaka; Kazuya Shimoda; Yukihiro Haruyama; Hiroaki Kataoka; Atsushi Nanashima

doi:10.1016/j.ijscr.2020.09.171

Diffuse large B-cell lymphoma of the gallbladder arised 8 years after malignant lymphoma of the right testis: A case report and literature review

Int J Surg Case Rep. 2020:76:19-24. doi: 10.1016/j.ijscr.2020.09.171. Epub 2020 Sep 28.

Authors

Affiliations

¹ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: kengo_kai@med.miyazaki-u.ac.jp.
² Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: takeomi_hamada@med.miyazaki-u.ac.jp.
³ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: mhiyoshi@med.miyazaki-u.ac.jp.
⁴ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: naoya_imamura@med.miyazaki-u.ac.jp.
⁵ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: k01yano@med.miyazaki-u.ac.jp.
⁶ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: motosurg@med.miyazaki-u.ac.jp.
⁷ Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: kaim@med.miyazaki-u.ac.jp.
⁸ Department of Haematology, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: tmnhdk@med.miyazaki-u.ac.jp.
⁹ Department of Haematology, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: kshimoda@med.miyazaki-u.ac.jp.
¹⁰ Section of Oncopathology and Regenerative Biology, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: yukihoro_haruyama@med.miyazaki-u.ac.jp.
¹¹ Section of Oncopathology and Regenerative Biology, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: mejina@med.miyazaki-u.ac.jp.
¹² Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki, 889-1692, Japan. Electronic address: a-nanashima@med.miyazaki-u.ac.jp.

Abstract

Introduction: Gallbladder involvement in lymphoma is extremely rare, and only 68 cases have been reported in the English literature so far. We experienced a case of diffuse large B-cell lymphoma (DLBCL) of the gallbladder arising 8 years after DLBCL of the right testis.

Presentation of case: A 68-year-old man underwent orchiectomy for malignant lymphoma of the right testis pathologically diagnosed as DLBCL 8 years ago. Systemic surveillance incidentally revealed a gallbladder tumour, and elective resection of the gallbladder bed of the liver was performed under a preoperative diagnosis of gallbladder cancer. The histopathological examination revealed DLBCL. At re-evaluation 3 months after surgery, he was diagnosed as having DLBCL involving the stomach. There had been no recurrence for 39 months after chemotherapy and radiation, but he suffered from a poor general condition due to protein-losing enteropathy and died of infection.

Discussion: We compiled and analysed reported cases of malignant lymphomas involving the gallbladder in terms of background, symptoms, imaging findings, and prognosis. Compared to MALT lymphoma, DLBCL was significantly more involved in other organs simultaneously or heterochronously (p = 0.004).

Conclusion: Gallbladder lymphoma should be added to the differential diagnosis of gallbladder tumours, especially when clinical findings are not consistent with the typical course of gallbladder carcinoma and cholecystitis.

Keywords: Diffuse large B-cell lymphoma; Gallbladder; Literature review; Prognosis; Testis.

Publication types

Case Reports