Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

Takashi Kikuchi; Naoki Motoyashiki; Takeshi Yamada; Kanae Shibatani; Kiyofumi Ninomiya; Toshio Morikawa; Reiko Tanaka

doi:10.3390/ijms18112479

Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

Int J Mol Sci. 2017 Nov 21;18(11):2479. doi: 10.3390/ijms18112479.

Authors

Takashi Kikuchi¹, Naoki Motoyashiki², Takeshi Yamada³, Kanae Shibatani⁴, Kiyofumi Ninomiya⁵, Toshio Morikawa⁶, Reiko Tanaka⁷

Affiliations

¹ Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. t.kikuchi@gly.oups.ac.jp.
² Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. mottchan050321@gmail.com.
³ Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. yamada@gly.oups.ac.jp.
⁴ Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. 1633420001c@kindai.ac.jp.
⁵ Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. ninomiya@phar.kindai.ac.jp.
⁶ Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan. morikawa@kindai.ac.jp.
⁷ Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan. tanakar@gly.oups.ac.jp.

Abstract

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.

Keywords: Pleurotus eryngii; aromatase inhibitor; ergostane; sterol.

MeSH terms

Agaricales / chemistry*
Aromatase / metabolism
Aromatase Inhibitors / chemistry
Aromatase Inhibitors / isolation & purification
Aromatase Inhibitors / pharmacology*
Biological Products / chemistry
Biological Products / isolation & purification
Biological Products / pharmacology*
Enzyme Activation / drug effects
Ergosterol / analogs & derivatives*
Ergosterol / chemistry
Ergosterol / isolation & purification
Ergosterol / pharmacology
Humans
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Molecular Structure

Substances

Aromatase Inhibitors
Biological Products
Aromatase
ergostane
Ergosterol