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Showing results for napqi song
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Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.
Fang Z, Xu Y, Liu G, Shao Q, Niu X, Tai W, Shen T, Fan M, Chen M, Lei L, Gao W, Song Y, Wang Z, Du X, Li X. Fang Z, et al. Autophagy. 2023 Aug;19(8):2240-2256. doi: 10.1080/15548627.2023.2179781. Epub 2023 Feb 24. Autophagy. 2023. PMID: 36779633 Free PMC article.
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential agent for treating APAP overdose.Abbreviations: ALP: autophagy-lysosomal pathway; APAP: acetaminophen; APAP-AD: APAP-protein adducts; APAP-Cys: …
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential age …
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning.
Chen Y, Song W, Ge W, Yan R. Chen Y, et al. Toxicol Sci. 2022 Sep 24;189(2):175-185. doi: 10.1093/toxsci/kfac082. Toxicol Sci. 2022. PMID: 35944217
APAP bioactivation in larval zebrafish was first confirmed by the detection of the glutathione conjugate of the reactive intermediate NAPQI (NAPQI-GSH) and subsequent mercapturate derivatives NAPQI-cysteine and NAPQI-N-acetylcysteine after even short ( …
APAP bioactivation in larval zebrafish was first confirmed by the detection of the glutathione conjugate of the reactive intermediate NAP …
An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice.
Park JH, Seo KS, Tadi S, Ahn BH, Lee JU, Heo JY, Han J, Song MS, Kim SH, Yim YH, Choi HS, Shong M, Kweon G. Park JH, et al. Antioxid Redox Signal. 2013 May 10;18(14):1713-22. doi: 10.1089/ars.2012.4677. Epub 2012 Dec 19. Antioxid Redox Signal. 2013. PMID: 23121402 Free PMC article.
Thus, blocking NAPQI formation or eliminating NAPQI are novel strategies for the treatment or prevention of APAP-induced liver injury instead of GSH replenishment. CONCLUSION: Our data suggest that the indole-derivative, NecroX-7, directly binds to NAPQI when …
Thus, blocking NAPQI formation or eliminating NAPQI are novel strategies for the treatment or prevention of APAP-induced liver …
Novel approach for evaluating pharmaceuticals toxicity using Daphnia model: analysis of the mode of cytochrome P450-generated metabolite action after acetaminophen exposure.
Kim RO, Jo MA, Song J, Kim IC, Yoon S, Kim WK. Kim RO, et al. Aquat Toxicol. 2018 Mar;196:35-42. doi: 10.1016/j.aquatox.2017.12.017. Epub 2017 Dec 30. Aquat Toxicol. 2018. PMID: 29328974
The present study aimed to develop reliable and sensitive markers for evaluation of APAP toxicity using Daphnia as a model organism. We focused on N-acetyl-p-benzoquinoneimine (NAPQI) production from APAP via cytochrome P450 metabolism because NAPQI causes APAP toxi …
The present study aimed to develop reliable and sensitive markers for evaluation of APAP toxicity using Daphnia as a model organism. We focu …