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Showing results for napqi liu
Your search for Naiqi Liu retrieved no results
Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin.
Fang Z, Xu Y, Liu G, Shao Q, Niu X, Tai W, Shen T, Fan M, Chen M, Lei L, Gao W, Song Y, Wang Z, Du X, Li X. Fang Z, et al. Autophagy. 2023 Aug;19(8):2240-2256. doi: 10.1080/15548627.2023.2179781. Epub 2023 Feb 24. Autophagy. 2023. PMID: 36779633 Free PMC article.
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential agent for treating APAP overdose.Abbreviations: ALP: autophagy-lysosomal pathway; APAP: acetaminophen; APAP-AD: APAP-protein adducts; APAP-Cys: …
Together, NR protects against APAP-induced liver injury by activating a PPP3/calcineurin-TFEB-ALP axis, indicating NR may be a potential age …
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites.
Xu Y, Xia Y, Liu Q, Jing X, Tang Q, Zhang J, Jia Q, Zhang Z, Li J, Chen J, Xiong Y, Li Y, He J. Xu Y, et al. J Pharm Anal. 2023 Dec;13(12):1548-1561. doi: 10.1016/j.jpha.2023.08.004. Epub 2023 Aug 9. J Pharm Anal. 2023. PMID: 38223455 Free PMC article.
Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF). ...
Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyt …
Maternal Administration of Acetaminophen Affects Meiosis Through its Metabolite NAPQI Targeting SIRT7 in Fetal Oocytes.
Liu F, He J, Chen X, Liu R, Li F, Geng Y, Dai Y, Zhang Y, Wang Y, Mu X. Liu F, et al. Antioxid Redox Signal. 2024 Feb 13. doi: 10.1089/ars.2023.0270. Online ahead of print. Antioxid Redox Signal. 2024. PMID: 38062739
Results: Pregnant mice at 14.5 dpc (days post-coitus) were orally administered with APAP (50 and 150mg/kg.bw/day) for 3 days; meanwhile, 14.5 dpc ovaries were collected and cultured with APAP or its metabolite N-acetyl-p-benzoquinone imine (NAPQI; 5 and 15 muM) for 3 days. …
Results: Pregnant mice at 14.5 dpc (days post-coitus) were orally administered with APAP (50 and 150mg/kg.bw/day) for 3 days; meanwhile, 14. …
The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury.
Liu FC, Yu HP, Liao CC, Chou AH, Lee HC. Liu FC, et al. Life (Basel). 2021 Oct 15;11(10):1094. doi: 10.3390/life11101094. Life (Basel). 2021. PMID: 34685467 Free PMC article.
Approximately 10% of APAP is metabolized by cytochrome P450 (CYP2E1) into toxic N-acetyl-p-benzoquinone imine (NAPQI). CYP2E1 also contributes to ethanol metabolism, especially during conditions of high blood ethanol concentration. ...
Approximately 10% of APAP is metabolized by cytochrome P450 (CYP2E1) into toxic N-acetyl-p-benzoquinone imine (NAPQI). CYP2E1 also co …
Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway.
Zhang J, Liang X, Li J, Yin H, Liu F, Hu C, Li L. Zhang J, et al. Front Pharmacol. 2020 Nov 20;11:549057. doi: 10.3389/fphar.2020.549057. eCollection 2020. Front Pharmacol. 2020. PMID: 33658919 Free PMC article.
MTT assay results revealed that API attenuated APAP and its metabolic product, N-acetyl-p-benzoquinone imine (NAPQI) induced cytotoxicity in a dose-dependent manner in human liver cells, L-02 cells. ...
MTT assay results revealed that API attenuated APAP and its metabolic product, N-acetyl-p-benzoquinone imine (NAPQI) induced cytotoxi …
Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury.
Zhou M, Wang M, Zhong RF, Liao XM, Deng LL, Xu GB, He X, Li J, Li YJ, Liu T, Wang YL, Liao SG. Zhou M, et al. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3636-3642. doi: 10.1016/j.bmcl.2017.07.028. Epub 2017 Jul 10. Bioorg Med Chem Lett. 2017. PMID: 28729056
Docking and drug-metabolizing activity studies demonstrated that CYP3A4 was likely the main target of auriculatone, and that auriculatone elicited the hepatoprotective effect possibly through inhibiting CYP3A4's metabolism of APAP to the toxic metabolite NAPQI. The work ma …
Docking and drug-metabolizing activity studies demonstrated that CYP3A4 was likely the main target of auriculatone, and that auriculatone el …
Practical and Sustainable Modification Method on Activated Carbon to Improve the Decolorization Process in the Acetaminophen Pharmaceutical Industry.
Liu H, Su Y, Liu C, Zhou A, Chu X, Liu S, Xing X, Tang E. Liu H, et al. ACS Omega. 2021 Feb 15;6(8):5451-5462. doi: 10.1021/acsomega.0c05637. eCollection 2021 Mar 2. ACS Omega. 2021. PMID: 33681585 Free PMC article.
Furthermore, according to the different catalytic results of O-T-RAC (thermal regeneration PAC modified by hydrogen peroxide) in solid-liquid catalytic and adsorption catalytic systems, we speculated that the multimer impurities were generated by the oxidative coupling reaction o …
Furthermore, according to the different catalytic results of O-T-RAC (thermal regeneration PAC modified by hydrogen peroxide) in solid-liqui …
13 results