Abstract
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole and 1,2,4-triazole-3-thione derivatives 21 and 23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide 1 in particular was found to have potent antioxidant and antitumor activity.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antioxidants / chemical synthesis
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Antioxidants / chemistry
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Antioxidants / pharmacology*
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Biphenyl Compounds / antagonists & inhibitors
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Cell Line, Tumor
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Cell Survival / drug effects
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Humans
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Hydrazines / chemistry
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Molecular Structure
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Nucleosides / chemical synthesis
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Nucleosides / chemistry
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Nucleosides / pharmacology*
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Oxadiazoles / chemistry
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Picrates / antagonists & inhibitors
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Structure-Activity Relationship
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Thiosemicarbazones / chemistry
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Triazoles / chemistry
Substances
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Antineoplastic Agents
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Antioxidants
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Biphenyl Compounds
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Hydrazines
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Nucleosides
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Oxadiazoles
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Picrates
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Thiosemicarbazones
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Triazoles
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1,1-diphenyl-2-picrylhydrazyl
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carbohydrazide