Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease.
Ferreira AF, Raposo M, Shaw ED, Ashraf NS, Medeiros F, Brilhante MF, Perkins M, Vasconcelos J, Kay T, Costa MDC, Lima M.
Ferreira AF, et al.
Cells. 2023 May 17;12(10):1404. doi: 10.3390/cells12101404.
Cells. 2023.
PMID: 37408238
Free PMC article.
Post-mortem MJD brains show increased BCL2/BAX transcript ratio in the dentate cerebellar nucleus (DCN) and increased BCL2/BAX insoluble protein ratio in the DCN and pons, suggesting that in these regions, severely affected by degeneration in MJD, cells show signs of apopt …
Post-mortem MJD brains show increased BCL2/BAX transcript ratio in the dentate cerebellar nucleus (DCN) and increased BCL2/BAX insoluble pro …