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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1967 3
1968 3
1975 1
1976 3
1977 1
1978 3
1979 3
1980 3
1981 4
1982 6
1983 9
1984 4
1985 6
1986 3
1987 3
1988 16
1989 11
1990 8
1991 4
1992 17
1993 22
1994 23
1995 27
1996 10
1997 25
1998 40
1999 34
2000 48
2001 54
2002 70
2003 88
2004 119
2005 264
2006 314
2007 319
2008 329
2009 341
2010 371
2011 413
2012 402
2013 451
2014 556
2015 579
2016 525
2017 530
2018 605
2019 631
2020 681
2021 749
2022 789
2023 652
2024 237

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9,130 results

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Page 1
The U6 snRNA m(6)A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.
Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK. Pendleton KE, et al. Cell. 2017 May 18;169(5):824-835.e14. doi: 10.1016/j.cell.2017.05.003. Cell. 2017. PMID: 28525753 Free PMC article.
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. We demonstrate that the N(6)-adenosine methyltransferase METTL16 regulates expression of human MAT2A, which encodes the SAM syn …
Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety of biological processes. W …
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Mendel M, Delaney K, Pandey RR, Chen KM, Wenda JM, Vågbø CB, Steiner FA, Homolka D, Pillai RS. Mendel M, et al. Cell. 2021 Jun 10;184(12):3125-3142.e25. doi: 10.1016/j.cell.2021.03.062. Epub 2021 Apr 29. Cell. 2021. PMID: 33930289 Free PMC article.
The N(6)-methyladenosine (m(6)A) RNA modification is used widely to alter the fate of mRNAs. ...The mechanism is triggered by a rich diet and acts as an m(6)A-mediated switch to stop SAM production and regulate its homeostasis. Although the mammalian SAM synt …
The N(6)-methyladenosine (m(6)A) RNA modification is used widely to alter the fate of mRNAs. ...The mechanism is triggered by a rich …
Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase.
Iyamu ID, Vilseck JZ, Yadav R, Noinaj N, Huang R. Iyamu ID, et al. Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202114813. doi: 10.1002/anie.202114813. Epub 2022 Feb 23. Angew Chem Int Ed Engl. 2022. PMID: 35134268 Free PMC article.
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide and has been associated with various diseases. ...Furthermore, this strategy provides the first case of introducing unconventional SAM mimics, which can be adopted to develop cell-potent inhibitors for …
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide and has been associated with various diseases. ...Furthermore, this s …
Radical SAM-mediated methylation reactions.
Fujimori DG. Fujimori DG. Curr Opin Chem Biol. 2013 Aug;17(4):597-604. doi: 10.1016/j.cbpa.2013.05.032. Epub 2013 Jul 5. Curr Opin Chem Biol. 2013. PMID: 23835516 Free PMC article. Review.
Recently, activities of several radical SAM methylating enzymes have been reconstituted in vitro and their mechanisms of catalysis investigated. ...Methylcobalamin serves as an intermediate methyl donor in TsrM, and is proposed to transfer the methyl group as a methyl radi …
Recently, activities of several radical SAM methylating enzymes have been reconstituted in vitro and their mechanisms of catalysis in …
Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
Li J, Sun C, Cai W, Li J, Rosen BP, Chen J. Li J, et al. Mutat Res Rev Mutat Res. 2021 Jul-Dec;788:108396. doi: 10.1016/j.mrrev.2021.108396. Epub 2021 Oct 7. Mutat Res Rev Mutat Res. 2021. PMID: 34893161 Free PMC article. Review.
As the second most ubiquitous cofactor in humans, S-adenosyl-l-methionine (SAM or AdoMet) serves as a methyl donor for SAM-dependent methyltransferases (MTases), which transfer a methyl group to a nucleophilic acceptor such as O, As, N, S, or C as the byprodu …
As the second most ubiquitous cofactor in humans, S-adenosyl-l-methionine (SAM or AdoMet) serves as a methyl donor for SAM-dep …
Diversity of the reaction mechanisms of SAM-dependent enzymes.
Sun Q, Huang M, Wei Y. Sun Q, et al. Acta Pharm Sin B. 2021 Mar;11(3):632-650. doi: 10.1016/j.apsb.2020.08.011. Epub 2020 Aug 26. Acta Pharm Sin B. 2021. PMID: 33777672 Free PMC article. Review.
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and S atoms in small-molecule secondary metabolites and macromolecules, including proteins and nucleic acids. ...Herein, we mainly describe the …
Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O, N, and …
Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection.
Lou G, Anderluzzi G, Schmidt ST, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson RN, Roberts CW, O'Hagan DT, Baudner BC, Perrie Y. Lou G, et al. J Control Release. 2020 Sep 10;325:370-379. doi: 10.1016/j.jconrel.2020.06.027. Epub 2020 Jul 1. J Control Release. 2020. PMID: 32619745 Free article.
The cationic lipids investigated included 3ss-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol (DC-Chol), dimethyldioctadecylammonium (DDA), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 1,2-dimyristoyl-3-trimethylammonium-propane (DMTAP), 1,2-stearoy …
The cationic lipids investigated included 3ss-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol (DC-Chol), dimethyld …
Radical SAM enzymes: Nature's choice for radical reactions.
Broderick JB, Broderick WE, Hoffman BM. Broderick JB, et al. FEBS Lett. 2023 Jan;597(1):92-101. doi: 10.1002/1873-3468.14519. Epub 2022 Oct 27. FEBS Lett. 2023. PMID: 36251330 Free PMC article. Review.
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form the largest enzyme superfamily, with over half a million members across the tree of life. ...The simplicity of SAM as a radical precurs …
Enzymes that use a [4Fe-4S](1+) cluster plus S-adenosyl-l-methionine (SAM) to initiate radical reactions (radical SAM) form th …
Complex roles of nicotinamide N-methyltransferase in cancer progression.
Wang W, Yang C, Wang T, Deng H. Wang W, et al. Cell Death Dis. 2022 Mar 25;13(3):267. doi: 10.1038/s41419-022-04713-z. Cell Death Dis. 2022. PMID: 35338115 Free PMC article. Review.
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-L-methionine (SAM) is the methyl donor. High expression of NNMT can al …
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (N …
Nicotinamide-N-methyltransferase regulates lipid metabolism via SAM and 1-methylnicotinamide in the AML12 hepatocyte cell line.
Yoda M, Mizuno R, Izumi Y, Takahashi M, Bamba T, Kawaoka S. Yoda M, et al. J Biochem. 2023 Jun 30;174(1):89-98. doi: 10.1093/jb/mvad028. J Biochem. 2023. PMID: 37014628
Nicotinamide-N-methyltransferase (NNMT) is an enzyme that consumes S-adenosyl-methionine (SAM) and nicotinamide (NAM) to produce S-adenosyl-homocysteine (SAH) and 1-methylnicotinamide (MNAM). ...Treating Nnmt RNAi AML12 cells with cycloleucine, an inhibitor of SA …
Nicotinamide-N-methyltransferase (NNMT) is an enzyme that consumes S-adenosyl-methionine (SAM) and nicotinamide (NAM) to produ …
9,130 results