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Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Change in Albuminuria and GFR Slope as Joint Surrogate End Points for Kidney Failure: Implications for Phase 2 Clinical Trials in CKD.
Heerspink HJL, Inker LA, Tighiouart H, Collier WH, Haaland B, Luo J, Appel GB, Chan TM, Estacio RO, Fervenza F, Floege J, Imai E, Jafar TH, Lewis JB, Kam-Tao Li P, Locatelli F, Maes BD, Perna A, Perrone RD, Praga M, Schena FP, Wanner C, Xie D, Greene T; on behalf of CKD-EPI CT. Heerspink HJL, et al. J Am Soc Nephrol. 2023 Jun 1;34(6):955-968. doi: 10.1681/ASN.0000000000000117. Epub 2023 Mar 15. J Am Soc Nephrol. 2023. PMID: 36918388 Clinical Trial.
Proteomic Investigation of Malignant Major Salivary Gland Tumors.
Seccia V, Navari E, Donadio E, Boldrini C, Ciregia F, Ronci M, Aceto A, Dallan I, Lucacchini A, Casani AP, Mazzoni MR, Giusti L. Seccia V, et al. Head Neck Pathol. 2020 Jun;14(2):362-373. doi: 10.1007/s12105-019-01040-2. Epub 2019 May 16. Head Neck Pathol. 2020. PMID: 31098787 Free PMC article.
The purpose of this study was to define the proteome profile of fine needle aspiration (FNA) samples of malignant major salivary gland tumors (MSGT) compared to benign counterparts, and to evaluate potential clinical correlations and future applications. Patients affected by MSGT …
The purpose of this study was to define the proteome profile of fine needle aspiration (FNA) samples of malignant major salivary gland tumor …
Cutaneous sensory and autonomic denervation in CADASIL.
Nolano M, Provitera V, Donadio V, Caporaso G, Stancanelli A, Califano F, Pianese L, Liguori R, Santoro L, Ragno M. Nolano M, et al. Neurology. 2016 Mar 15;86(11):1039-44. doi: 10.1212/WNL.0000000000002468. Epub 2016 Feb 12. Neurology. 2016. PMID: 26873958
OBJECTIVE: To assess the involvement of the peripheral nervous system in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) by means of immunofluorescence and confocal analysis of punch skin biopsies. METHODS: We recruited 14 unre …
OBJECTIVE: To assess the involvement of the peripheral nervous system in cerebral autosomal dominant arteriopathy with subcortical infarcts …
Characterization of N-glycans of recombinant human thyrotropin using mass spectrometry.
Morelle W, Donadio S, Ronin C, Michalski JC. Morelle W, et al. Rapid Commun Mass Spectrom. 2006;20(3):331-45. doi: 10.1002/rcm.2289. Rapid Commun Mass Spectrom. 2006. PMID: 16372382
In this paper we report the first detailed structural characterization of the N-linked oligosaccharides of recombinant human thyroid-stimulating hormone (rhTSH). Using a strategy combining mass spectrometric analysis and sequential exoglycosidase digestion, we have defined …
In this paper we report the first detailed structural characterization of the N-linked oligosaccharides of recombinant human thyroid- …
Clinical Reasoning: Young woman with orbital pain and diplopia.
Infante R, Donadio V, Nucera B, Toni F, Marliani F, Liguori R, Licchetta L. Infante R, et al. Neurology. 2020 Feb 18;94(7):e752-e757. doi: 10.1212/WNL.0000000000008975. Epub 2020 Feb 3. Neurology. 2020. PMID: 32015178 No abstract available.
Role of glucocorticoid receptor polymorphism in adrenal incidentalomas.
Morelli V, Donadio F, Eller-Vainicher C, Cirello V, Olgiati L, Savoca C, Cairoli E, Salcuni AS, Beck-Peccoz P, Chiodini I. Morelli V, et al. Eur J Clin Invest. 2010 Sep;40(9):803-11. doi: 10.1111/j.1365-2362.2010.02330.x. Epub 2010 Jun 23. Eur J Clin Invest. 2010. PMID: 20584071
Patients with wild-type BclI, wild-type N363S and heterozygous BclI polymorphism were classified as carriers of haplotype 1 (H1; n = 86), patients with homozygous BclI and heterozygous N363S polymorphism of GR of haplotype 2 (H2; n = 14). RESULTS: We found no clinic …
Patients with wild-type BclI, wild-type N363S and heterozygous BclI polymorphism were classified as carriers of haplotype 1 (H1; n = …
Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.
Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL, Les AS, Collins P, Gregg KM, Di J, Lu Y, Tudor IC, Wyman BT, Booth K, Broome S, Yuen E, Grundman M, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Liu E, et al. Neurology. 2015 Aug 25;85(8):692-700. doi: 10.1212/WNL.0000000000001877. Epub 2015 Jul 24. Neurology. 2015. PMID: 26208959 Free PMC article. Clinical Trial.