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Dominant suppression of inflammation by glycan-hydrolyzed IgG.
Nandakumar KS, Collin M, Happonen KE, Croxford AM, Lundström SL, Zubarev RA, Rowley MJ, Blom AM, Holmdahl R. Nandakumar KS, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10252-7. doi: 10.1073/pnas.1301480110. Epub 2013 May 13. Proc Natl Acad Sci U S A. 2013. PMID: 23671108 Free PMC article. Retracted.
IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by f …
IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (Endo …
Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis.
Schoen C, Blom J, Claus H, Schramm-Glück A, Brandt P, Müller T, Goesmann A, Joseph B, Konietzny S, Kurzai O, Schmitt C, Friedrich T, Linke B, Vogel U, Frosch M. Schoen C, et al. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3473-8. doi: 10.1073/pnas.0800151105. Epub 2008 Feb 27. Proc Natl Acad Sci U S A. 2008. PMID: 18305155 Free PMC article.
The expression of a polysaccharide capsule is the only trait that has been convincingly linked to the pathogenic potential of N. meningitidis. To gain insight into the evolution of virulence traits in this species, whole-genome sequences of three meningococcal carriage iso …
The expression of a polysaccharide capsule is the only trait that has been convincingly linked to the pathogenic potential of N. meni …
Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection.
Ngampasutadol J, Ram S, Blom AM, Jarva H, Jerse AE, Lien E, Goguen J, Gulati S, Rice PA. Ngampasutadol J, et al. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17142-7. doi: 10.1073/pnas.0506471102. Epub 2005 Nov 7. Proc Natl Acad Sci U S A. 2005. PMID: 16275906 Free PMC article.
Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind the classical pathway of complement down-regulatory protein C4b-binding protein (C4bp) to evade killing by human …
Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane por …
Stepwise solvation of an amino acid: the appearance of zwitterionic structures.
Blom MN, Compagnon I, Polfer NC, Helden Gv, Meijer G, Suhai S, Paizs B, Oomens J. Blom MN, et al. J Phys Chem A. 2007 Aug 9;111(31):7309-16. doi: 10.1021/jp070211r. Epub 2007 Jul 12. J Phys Chem A. 2007. PMID: 17628045
Compelling evidence for a gradual transition to zwitterionic structures comes from tryptophan-methanol complexes up to n = 9. Starting from n = 5, the infrared spectra show increasing intensity in the diagnostic asymmetric COO- stretch and in the weaker NH3+ bending …
Compelling evidence for a gradual transition to zwitterionic structures comes from tryptophan-methanol complexes up to n = 9. Startin …
Inhibition of methylation and changes in gene expression in relation to neural tube defects.
van der Linden IJ, Heil SG, van Egmont Petersen M, van Straaten HW, den Heijer M, Blom HJ. van der Linden IJ, et al. Birth Defects Res A Clin Mol Teratol. 2008 Oct;82(10):676-83. doi: 10.1002/bdra.20509. Birth Defects Res A Clin Mol Teratol. 2008. PMID: 18937356
Gene expression profiling was determined using the Affymetrix Genechip Chicken Genome Array on RNA isolated from two pools of Adox-treated cranial parts (n = 12) and two pools of saline-treated cranial parts (n = 12). ...
Gene expression profiling was determined using the Affymetrix Genechip Chicken Genome Array on RNA isolated from two pools of Adox-treated c …