Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8+ T cells.
Winkler F, Hipp AV, Ramirez C, Martin B, Villa M, Neuwirt E, Gorka O, Aerssens J, Johansson SE, Rana N, Llewellyn-Lacey S, Price DA, Panning M, Groß O, Pearce EL, Hermann CM, Schumann K, Hannibal L, Neumann-Haefelin C, Boettler T, Knolle P, Hofmann M, Wohlleber D, Thimme R, Bengsch B.
Winkler F, et al. Among authors: ramirez c.
Gut. 2023 Oct;72(10):1971-1984. doi: 10.1136/gutjnl-2022-328734. Epub 2023 Aug 4.
Gut. 2023.
PMID: 37541771
Free PMC article.
DESIGN: Metabolic state, exhaustion and transcriptome of virus-specific CD8(+) T cells from chronic HBV-infected (n=31) and HCV-infected patients (n=52) were determined ex vivo and during direct-acting antiviral (DAA) therapy. ...
DESIGN: Metabolic state, exhaustion and transcriptome of virus-specific CD8(+) T cells from chronic HBV-infected (n=31) and HCV-infec …