Experimental results for homogeneous nucleation of water droplets in the presence of argon, nitrogen, and, for the first time, nitrous oxide as carrier gases are reported. The main objective of the study was to investigate the effects of different carrier gases on the nucleation rate. These gases differ in the number of atoms comprising the molecule, which affects the expansion ratio required to reach the target nucleation temperature. The experiments cover nucleation temperatures from 220 to 260 K, nucleation pressures from 40 to 73 kPa, supersaturations of 6.5-20, and nucleation rates ranging from about 4 × 105 to 4 × 109 cm-3 s-1. The new data obtained with a modernized expansion chamber utilizing the nucleation pulse method show good agreement with the available literature data. Another important point of our work is the application of real gas corrections to calculate the nucleation temperature and supersaturation. The results show that the influence of carrier gases on nucleation rate in the investigated pressure range is modest (less than a factor of 7), while without the real gas correction, the apparent effect of carrier gas is significant, with differences as high as a factor of 90.