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Showing results for mucin wang
Search for Muxin Wang instead (1 results)
Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway.
Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Lv J, et al. Nat Cell Biol. 2022 Mar;24(3):364-372. doi: 10.1038/s41556-022-00857-4. Epub 2022 Mar 15. Nat Cell Biol. 2022. PMID: 35292781 Free PMC article.
Inoculation of GSDME(-/-) PDAC cells results in subcutaneous but not orthotopic tumour formation in mice. Inhibition or knockout of mucin 1 or mucin 13 abrogates orthotopic PDAC growth in NOD-SCID mice. Mechanistically, GSDME interacts with and transports YBX1 into …
Inoculation of GSDME(-/-) PDAC cells results in subcutaneous but not orthotopic tumour formation in mice. Inhibition or knockout of mucin …
Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface.
Chatterjee M, Huang LZX, Mykytyn AZ, Wang C, Lamers MM, Westendorp B, Wubbolts RW, van Putten JPM, Bosch BJ, Haagmans BL, Strijbis K. Chatterjee M, et al. PLoS Pathog. 2023 Aug 10;19(8):e1011571. doi: 10.1371/journal.ppat.1011571. eCollection 2023 Aug. PLoS Pathog. 2023. PMID: 37561789 Free PMC article.
The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance. ...In this study, we determined the impact of host mucins and mucin glycans on epithelial entry of SARS-CoV-2. Human lung epithelial Calu-3 cells expr …
The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by mucociliary clearance. ...In this study, we det …
Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17.
Wang Y, Lou R, Zhang Z, Xiao C, Yu S, Wei S, Liu Y, Fu W, Li B, Chen YG. Wang Y, et al. Sci Adv. 2023 Oct 27;9(43):eadi1827. doi: 10.1126/sciadv.adi1827. Epub 2023 Oct 27. Sci Adv. 2023. PMID: 37889976 Free PMC article.
Interleukin (IL) secretion by stromal cells is notably increased, including IL-1, IL-11, and IL-17. Specifically, IL-1 and IL-17a hyperactivate the mucin production by goblet cells through nuclear factor kappaB signaling, and abnormal mucin accumulation results in t …
Interleukin (IL) secretion by stromal cells is notably increased, including IL-1, IL-11, and IL-17. Specifically, IL-1 and IL-17a hyperactiv …
Muc2 mucin O-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway.
Wei J, Chen C, Feng J, Zhou S, Feng X, Yang Z, Lu H, Tao H, Li L, Xv H, Xuan J, Wang F. Wei J, et al. J Transl Med. 2023 Nov 8;21(1):793. doi: 10.1186/s12967-023-04687-2. J Transl Med. 2023. PMID: 37940996 Free PMC article.
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by a compromised intestinal epithelial barrier. Mucin glycans are crucial in preserving barrier function during bacterial infections, although the underlying mechanisms rem …
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine characterized by a compromised intestinal epithelial …
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment.
Schwabkey ZI, Wiesnoski DH, Chang CC, Tsai WB, Pham D, Ahmed SS, Hayase T, Ortega Turrubiates MR, El-Himri RK, Sanchez CA, Hayase E, Frenk Oquendo AC, Miyama T, Halsey TM, Heckel BE, Brown AN, Jin Y, Raybaud M, Prasad R, Flores I, McDaniel L, Chapa V, Lorenzi PL, Warmoes MO, Tan L, Swennes AG, Fowler S, Conner M, McHugh K, Graf T, Jensen VB, Peterson CB, Do KA, Zhang L, Shi Y, Wang Y, Galloway-Pena JR, Okhuysen PC, Daniel-MacDougall CR, Shono Y, Burgos da Silva M, Peled JU, van den Brink MRM, Ajami N, Wargo JA, Reddy P, Valdivia RH, Davey L, Rondon G, Srour SA, Mehta RS, Alousi AM, Shpall EJ, Champlin RE, Shelburne SA, Molldrem JJ, Jamal MA, Karmouch JL, Jenq RR. Schwabkey ZI, et al. Sci Transl Med. 2022 Nov 16;14(671):eabo3445. doi: 10.1126/scitranslmed.abo3445. Epub 2022 Nov 16. Sci Transl Med. 2022. PMID: 36383683 Free PMC article.
A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of Akkermansia muciniphila, a species of mucin-degrading bacteria (P = 0.006, corrected for multiple comparisons). ...Culturing A. muciniphila in v …
A total of 63 patients (53%) developed a subsequent fever, and their fecal microbiome displayed increased relative abundances of Akkermansia …
Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway.
Wang B, Zhang J, Liu X, Chai Q, Lu X, Yao X, Yang Z, Sun L, Johnson SF, Schwartz RC, Zheng YH. Wang B, et al. Autophagy. 2022 Oct;18(10):2350-2367. doi: 10.1080/15548627.2022.2031381. Epub 2022 Feb 7. Autophagy. 2022. PMID: 35130104 Free PMC article.
We suggest that ebolaviruses hijack the host protein folding and ERAD machinery to increase their fitness via reticulophagy during infection.Abbreviations: 3-MA: 3-methyladenine; 4-PBA: 4-phenylbutyrate; ACTB: beta-actin; ATF: activating transcription factor; ATG: autophagy-relat …
We suggest that ebolaviruses hijack the host protein folding and ERAD machinery to increase their fitness via reticulophagy during infection …
The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation.
Qu D, Wang G, Yu L, Tian F, Chen W, Zhai Q. Qu D, et al. Carbohydr Polym. 2021 Apr 15;258:117651. doi: 10.1016/j.carbpol.2021.117651. Epub 2021 Jan 19. Carbohydr Polym. 2021. PMID: 33593539 Review.
Intestinal mucins glycosylation is regulated by host cues and environmental signals from the microbiome and diets. ...In this review, the dynamic alterations of mucin glycosylation induced by immune responses to gut diseases are summarized. ...
Intestinal mucins glycosylation is regulated by host cues and environmental signals from the microbiome and diets. ...In this review, …
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Biering SB, et al. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. Nat Genet. 2022. PMID: 35879412 Free PMC article.
We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weig …
We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling …
Hyper Expression of Mucin 5ac Indicates Poor Cancer Prognoses: A Meta-Analysis.
Wang X, Yan F, Shi R, Huang X, Lu S, Xu L, Ren B. Wang X, et al. Medicine (Baltimore). 2016 Jan;95(1):e2396. doi: 10.1097/MD.0000000000002396. Medicine (Baltimore). 2016. PMID: 26735541 Free PMC article. Review.
The prognostic value of mucin 5ac expression in cancer patients was evaluated. The overexpression of mucin 5ac was found to be significantly associated with a poor prognosis in cancer patients (pooled HR: 1.53, 95%CI: 1.158-2.028, P = 0.003). ...In the clinical char …
The prognostic value of mucin 5ac expression in cancer patients was evaluated. The overexpression of mucin 5ac was found to be …
Correlation between mucin biology and tumor heterogeneity in lung cancer.
Xu M, Wang DC, Wang X, Zhang Y. Xu M, et al. Semin Cell Dev Biol. 2017 Apr;64:73-78. doi: 10.1016/j.semcdb.2016.08.027. Epub 2016 Aug 26. Semin Cell Dev Biol. 2017. PMID: 27569189 Review.
Mucins (MUC) are a family consisting of large O-glycoproteins whose primary functions are to protect and lubricate cell epithelial surfaces and contribute to intra- and inter-cellular signal pathways, cell proliferation, growth and apotosis. ...
Mucins (MUC) are a family consisting of large O-glycoproteins whose primary functions are to protect and lubricate cell epithelial su …
4,020 results