Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis.
Meng Z, Zhang S, Li W, Wang Y, Wang M, Liu X, Liu CL, Liao S, Liu T, Yang C, Lindholt JS, Rasmussen LM, Obel LM, Stubbe J, Diederichsen AC, Sun Y, Chen Y, Yu PB, Libby P, Shi GP, Guo J.
Meng Z, et al.
Eur Heart J. 2023 Aug 1;44(29):2763-2783. doi: 10.1093/eurheartj/ehad262.
Eur Heart J. 2023.
PMID: 37279475
Free PMC article.
Eosinophil deficiency in deltadblGATA mice slowed atherogenesis with increased lesion smooth muscle cell (SMC) content and reduced calcification. This protection in deltadblGATA mice was muted when mice received donor eosinophils from wild-type (WT), Il4-/-, and Il13-/- mi …
Eosinophil deficiency in deltadblGATA mice slowed atherogenesis with increased lesion smooth muscle cell (SMC) content and reduced calcifica …