New Therapeutic Strategies for the Inflammatory Rheumatoid Arthritis Disease: Emphasizing Mesenchymal Stem Cells and Associated exo-miRNA or exo-lncRNA

Shadia Faris Ahmed; Saade Abdalkareem Jasim; Harikumar Pallathadka; Harpreet Kaur; S Renuka Jyothi; Pooja Bansal; Hussam Abdali; Yasser Fakri Mustafa; Salah Hassan Zain Al-Abdeen; Ahmed Hussein Zwamel

doi:10.1007/s12013-024-01316-7

New Therapeutic Strategies for the Inflammatory Rheumatoid Arthritis Disease: Emphasizing Mesenchymal Stem Cells and Associated exo-miRNA or exo-lncRNA

Cell Biochem Biophys. 2024 May 31. doi: 10.1007/s12013-024-01316-7. Online ahead of print.

Authors

Affiliations

¹ Biology Department, College of Science, University of Sulaimani, Sulaymaniyah, Iraq.
² Medical Laboratory Techniques Department, Al-maarif University College, Anbar, Iraq. saade.a.j@uoa.edu.iq.
³ Biotechnology Department, College of Applied Science, Fallujah University, Fallujah, Iraq. saade.a.j@uoa.edu.iq.
⁴ Manipur International University, Imphal, Manipur, India. pallathadkaharikumar1402@gmail.com.
⁵ Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
⁶ School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
⁷ Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
⁸ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
⁹ Department of Medical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
¹¹ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
¹² Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.
¹³ Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹⁴ Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq.

PMID: 38822204
DOI: 10.1007/s12013-024-01316-7

Abstract

The most prevalent inflammatory arthritis and a leading contributor to disability is rheumatoid arthritis (RA). Although it may not have arrived in Europe until the 17th century, it was present in early Native American communities several thousand years ago. Exosomes released by mesenchymal stem cells (MSCs) are highly immunomodulatory due to the origin of the cell. As a cell-free therapy, MSCs-exosomes are less toxic and elicit a weakened immune response than cell-based therapies. Exosomal noncoding RNAs (ncRNAs) are closely associated with a number of biological and functional facets of human health, especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Various exo-miRNAs and lncRNAs such as HAND2-AS1, miR-150-5p, miRNA-124a, and miR-320a lodged with MSC could be appropriate therapeutic ways for RA treatment. These MSC-derived exosomes affect RA disorders via different molecular pathways such as NFK-β, MAPK, and Wnt. The purpose of this review is to review the research that has been conducted since 2020 so far in the field of RA disease treatment with MSC-loaded exo-miRNAs and exo-lncRNAs.

Keywords: Autoimmune; Mesenchymal stem cell; Rheumatoid Arthritis (RA); lncRNA; miRNA.

Publication types

Review