PMMA/ABS/CoCl2 Composites for Pharmaceutical Applications: Thermal, Antimicrobial, Antibiofilm, and Antioxidant Studies

Molecules. 2022 Nov 8;27(22):7669. doi: 10.3390/molecules27227669.

Abstract

In this study, PMMA/ABS/CoCl2 ternary composite films were fabricated by the solution casting technique. The different weight ratios of cobalt chloride (≤10 wt) were incorporated into the PMMA/ABS blend (80:20). The chemical structure and thermal properties of the synthesized composites were assessed by FT-IR, TGA, and XRD. The biological properties of ternary composites, such as in vitro antibacterial activity and antioxidant capacity, were investigated. The enhanced thermal stability and promising antibacterial, selective antibiofilm, and potential antioxidant properties of PMMA/ABS/cobalt chloride composites demonstrated that they can be used for high-quality plastics and in many pharmaceutical applications.

Keywords: bacteria; biofilms; degradation; inorganic filler.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / chemistry
  • Anti-Infective Agents* / pharmacology
  • Antioxidants* / pharmacology
  • Biofilms
  • Pharmaceutical Preparations
  • Polymethyl Methacrylate / chemistry
  • Spectroscopy, Fourier Transform Infrared

Substances

  • cobaltous chloride
  • Antioxidants
  • Polymethyl Methacrylate
  • Anti-Infective Agents
  • Anti-Bacterial Agents
  • Pharmaceutical Preparations

Grants and funding

This work was supported by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia (grant no. Grant1869).