SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma.
Li Z, Liao X, Hu Y, Li M, Tang M, Zhang S, Mo S, Li X, Chen S, Qian W, Feng R, Yu R, Xu Y, Yuan S, Xie C, Li J.
Li Z, et al.
Free Radic Biol Med. 2023 May 20;201:41-54. doi: 10.1016/j.freeradbiomed.2023.03.013. Epub 2023 Mar 15.
Free Radic Biol Med. 2023.
PMID: 36924851
Lipidomic analysis revealed that overexpression of SLC27A4 significantly promoted the selective uptake of mono-unsaturated fatty acids (MUFAs), which induced a high level of MUFA-containing phosphatidylcholine and phosphatidylethanolamine in HCC cells, consequently resulti …
Lipidomic analysis revealed that overexpression of SLC27A4 significantly promoted the selective uptake of mono-unsaturated fatty acids (MUFA …