D-Type Cyclins in Development and Disease

Mostafa Saleban; Erica L Harris; James A Poulter

doi:10.3390/genes14071445

D-Type Cyclins in Development and Disease

Genes (Basel). 2023 Jul 14;14(7):1445. doi: 10.3390/genes14071445.

Authors

Mostafa Saleban¹, Erica L Harris¹, James A Poulter¹

Affiliation

¹ Division of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds LS2 9JT, UK.

Abstract

D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D-type cyclins resulting in abnormal initiation of stem cell differentiation in a variety of different organ systems. Furthermore, stabilisation of D-type cyclins is observed in a wide range of disorders characterized by cellular over-proliferation, including cancers and overgrowth disorders. In this review, we will summarize and compare the roles played by each D-type cyclin during development and provide examples of how their intracellular dysregulation can be an underlying cause of disease.

Keywords: CDK4; cancer; cell cycle; cyclin D1; cyclin D2; cyclin D3; overgrowth; proliferation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Cycle / genetics
Cell Division
Cell Proliferation
Cyclin D3
Cyclins* / genetics
Cyclins* / metabolism

Substances

Cyclins
Cyclin D3

Grants and funding

This research was funded by a Future Leaders Fellowship to J.A.P. from UK Research and Innovation, grant number MR/T02044X/1, and a University Academic Fellowship to J.A.P. from the University of Leeds. The APC was funded by UK Research and Innovation.