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GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation.
Gauthier AG, Lin M, Zefi S, Kulkarni A, Thakur GA, Ashby CR Jr, Mantell LL. Gauthier AG, et al. Among authors: lin m. Redox Biol. 2023 Apr;60:102614. doi: 10.1016/j.redox.2023.102614. Epub 2023 Jan 20. Redox Biol. 2023. PMID: 36717349 Free PMC article.
The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages.
Gauthier AG, Wu J, Lin M, Sitapara R, Kulkarni A, Thakur GA, Schmidt EE, Perron JC, Ashby CR Jr, Mantell LL. Gauthier AG, et al. Among authors: lin m. Antioxidants (Basel). 2021 Jan 19;10(1):135. doi: 10.3390/antiox10010135. Antioxidants (Basel). 2021. PMID: 33477969 Free PMC article.
The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.
Sitapara RA, Gauthier AG, Valdés-Ferrer SI, Lin M, Patel V, Wang M, Martino AT, Perron JC, Ashby CR Jr, Tracey KJ, Pavlov VA, Mantell LL. Sitapara RA, et al. Among authors: lin m. Mol Med. 2020 Jun 29;26(1):63. doi: 10.1186/s10020-020-00177-z. Mol Med. 2020. PMID: 32600307 Free PMC article.
15 results