Interstitial lung disease associated with docetaxel in a patient treated for breast cancer - a case report

Pneumonol Alergol Pol. 2015;83(5):378-82. doi: 10.5603/PiAP.2015.0060.

Abstract

Docetaxel is a semisynthetic cytostatic drug that belongs to the family of taxoids. Docetaxel inhibits normal interphase and mitotic cellular function, causing cell death. Docetaxel is indicated for the treatment of breast, lung and prostate cancers, head and neck cancer and gastric adenocarcinoma. Interstitial pneumonitis is an uncommon side effect of docetaxel. We report a case of docetaxel induced interstitial lung disease (ILD) in a patient with breast cancer.

Keywords: breast cancer; docetaxel; interstitial lung disease.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Breast Neoplasms / complications
  • Breast Neoplasms / drug therapy*
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Docetaxel
  • Doxorubicin / administration & dosage
  • Doxorubicin / adverse effects
  • Female
  • Humans
  • Lung Diseases, Interstitial / chemically induced*
  • Lung Diseases, Interstitial / diagnosis*
  • Lung Diseases, Interstitial / diagnostic imaging
  • Lung Diseases, Interstitial / drug therapy
  • Middle Aged
  • Taxoids / adverse effects*
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents
  • Taxoids
  • Docetaxel
  • Doxorubicin
  • Cyclophosphamide