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Page 1
RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content.
Plant Cell Rep. 2021 Sep;40(9):1631-1646. doi: 10.1007/s00299-021-02707-3. Epub 2021 Jun 19.
Plant Cell Rep. 2021.
PMID: 34146141
Free PMC article.
Knockout of Arabidopsis thaliana VEP1, Encoding a PRISE (Progesterone 5β-Reductase/Iridoid Synthase-Like Enzyme), Leads to Metabolic Changes in Response to Exogenous Methyl Vinyl Ketone (MVK).
Klein J, Ernst M, Christmann A, Tropper M, Leykauf T, Kreis W, Munkert J.
Klein J, et al. Among authors: ernst m.
Metabolites. 2021 Dec 23;12(1):11. doi: 10.3390/metabo12010011.
Metabolites. 2021.
PMID: 35050133
Free PMC article.
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Overexpression and RNAi-mediated Knockdown of Two 3β-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis.
Leykauf T, Klein J, Ernst M, Dorfner M, Ignatova A, Kreis W, Lanig H, Munkert J.
Leykauf T, et al. Among authors: ernst m.
Planta Med. 2023 Jul;89(8):833-847. doi: 10.1055/a-2074-9186. Epub 2023 May 15.
Planta Med. 2023.
PMID: 37187191
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Steroid 5β-Reductase from Leaves of Vitis vinifera: Molecular Cloning, Expression, and Modeling.
Ernst M, Munkert J, Campa M, Malnoy M, Martens S, Müller-Uri F.
Ernst M, et al.
J Agric Food Chem. 2015 Nov 25;63(46):10112-20. doi: 10.1021/acs.jafc.5b04261. Epub 2015 Nov 13.
J Agric Food Chem. 2015.
PMID: 26537436
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Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH.
Ernst M, de Padua RM, Herl V, Müller-Uri F, Kreis W.
Ernst M, et al.
Planta Med. 2010 Jun;76(9):923-7. doi: 10.1055/s-0030-1250007. Epub 2010 May 31.
Planta Med. 2010.
PMID: 20514608
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Identification and stress-induced expression of three 3β-hydroxysteroid dehydrogenases from Erysimum crepidifolium Rchb. and their putative role in cardenolide biosynthesis.
Munkert J, Ernst M, Müller-Uri F, Kreis W.
Munkert J, et al. Among authors: ernst m.
Phytochemistry. 2014 Apr;100:26-33. doi: 10.1016/j.phytochem.2014.01.006. Epub 2014 Feb 7.
Phytochemistry. 2014.
PMID: 24512841
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