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Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors.
Shaaban MM, Ragab HM, Akaji K, McGeary RP, Bekhit AA, Hussein WM, Kurz JL, Elwakil BH, Bekhit SA, Ibrahim TM, Mahran MA, Bekhit AA. Shaaban MM, et al. Among authors: mahran ma. Bioorg Chem. 2020 Dec;105:104386. doi: 10.1016/j.bioorg.2020.104386. Epub 2020 Oct 20. Bioorg Chem. 2020. PMID: 33137556
Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis.
Abdelaziz ME, El-Miligy MMM, Fahmy SM, Abu-Serie MM, Hazzaa AA, Mahran MA. Abdelaziz ME, et al. Among authors: mahran ma. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2304044. doi: 10.1080/14756366.2024.2304044. Epub 2024 Jan 17. J Enzyme Inhib Med Chem. 2024. PMID: 38230430 Free PMC article.