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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors.
Bioorg Med Chem Lett. 2021 Feb 1;33:127753. doi: 10.1016/j.bmcl.2020.127753. Epub 2020 Dec 28.
Bioorg Med Chem Lett. 2021.
PMID: 33359168
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor.
Tsuboi K, Kimura H, Nakatsuji Y, Kassai M, Deai Y, Isobe Y.
Tsuboi K, et al. Among authors: kassai m.
Bioorg Med Chem Lett. 2021 Jul 15;44:128115. doi: 10.1016/j.bmcl.2021.128115. Epub 2021 May 17.
Bioorg Med Chem Lett. 2021.
PMID: 34015507
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The Impact of Intestinal Microbiota and Toll-like Receptor 2 Signaling on α-Synuclein Pathology in Nontransgenic Mice Injected with α-Synuclein Preformed Fibrils.
Koyanagi Y, Kassai M, Yoneyama H.
Koyanagi Y, et al. Among authors: kassai m.
Microorganisms. 2024 Jan 5;12(1):106. doi: 10.3390/microorganisms12010106.
Microorganisms. 2024.
PMID: 38257933
Free PMC article.
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Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators.
Hirose W, Kato Y, Yamamoto T, Kassai M, Takata M, Hayashi S, Arai Y, Imai S, Yoshida K.
Hirose W, et al. Among authors: kassai m.
Bioorg Med Chem Lett. 2016 Aug 15;26(16):3866-9. doi: 10.1016/j.bmcl.2016.07.019. Epub 2016 Jul 9.
Bioorg Med Chem Lett. 2016.
PMID: 27432763
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DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity.
Kato T, Takata M, Kitaichi M, Kassai M, Inoue M, Ishikawa C, Hirose W, Yoshida K, Shimizu I.
Kato T, et al. Among authors: kassai m.
Eur J Pharmacol. 2015 Jun 15;757:11-20. doi: 10.1016/j.ejphar.2015.03.024. Epub 2015 Mar 28.
Eur J Pharmacol. 2015.
PMID: 25823809
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