Abstract
Condensation of 4-aminophenylacetic acid with phthalic anhydride gave (dioxoisoindolin-2-yl)phenylacetic acid (1), which was employed as the key intermediate in the synthesis of title compounds 2-8. The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Antimicrobial activities were studied and some of the compounds showed promising results.
MeSH terms
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Aniline Compounds / chemical synthesis
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Aniline Compounds / pharmacology*
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology*
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Disk Diffusion Antimicrobial Tests
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Fungi / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Phenylacetates / chemical synthesis
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Phenylacetates / pharmacology*
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Spectrum Analysis
Substances
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Aniline Compounds
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Anti-Infective Agents
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Phenylacetates
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4-aminophenylacetic acid