Nanosized ZSM-5 will improve photodynamic therapy using Methylene blue

J Photochem Photobiol B. 2015 Jul:148:107-112. doi: 10.1016/j.jphotobiol.2015.03.013. Epub 2015 Apr 2.

Abstract

Nowadays, nanotechnology is growing to improve Photodynamic Therapy and reduce its side effects. In this research, the synthesized co-polymeric Zeolite Secony Mobile-5 (ZSM-5) was employed to modify Methylene Blue (MB) for these reasons. UV-Visible, FTIR, XRD analysis and SEM images were used to investigate obtained nanostructure. The crystal size for these nanostructures were determined 75 nm and maximum adsorption capacity of MB in the nanostructure was estimated 111 (mg g(-1)). Also, the role of Polyethylene Glycol (PEG) was studied as a capable non-toxic polymeric coating to overcome biological barriers. Moreover, potential of singlet oxygen production of the synthesized nanostructure was compared with MB and ZSM-5 nanoparticles control samples. Synthesized nanodrugs show impressive light induced singlet oxygen production efficiency.

MeSH terms

  • Light
  • Methylene Blue / chemistry*
  • Nanoparticles / chemistry
  • Nanoparticles / ultrastructure
  • Oxidation-Reduction
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Singlet Oxygen / metabolism
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Zeolites / chemistry*

Substances

  • ZSM-5 zeolite
  • Zeolites
  • Singlet Oxygen
  • Polyethylene Glycols
  • Methylene Blue