Abstract
A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2,2'-Dipyridyl / analogs & derivatives
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2,2'-Dipyridyl / chemistry*
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2,2'-Dipyridyl / pharmacology
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Antitubercular Agents / chemistry*
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Antitubercular Agents / pharmacology
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Electrochemistry
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Ligands
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / metabolism
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Organometallic Compounds / chemistry*
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Organometallic Compounds / pharmacology
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Ruthenium / chemistry*
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Ruthenium / pharmacology
Substances
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Antitubercular Agents
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Ligands
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Organometallic Compounds
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2,2'-Dipyridyl
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Ruthenium