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Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB. Bradley SJ, et al. Among authors: scarpa m. Nat Chem Biol. 2020 Mar;16(3):240-249. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20. Nat Chem Biol. 2020. PMID: 32080630 Free article.
M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB. Dwomoh L, et al. Among authors: scarpa m. Sci Signal. 2022 Nov 15;15(760):eabm3720. doi: 10.1126/scisignal.abm3720. Epub 2022 Nov 15. Sci Signal. 2022. PMID: 36378750 Free article.
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system.
Birgül Iyison N, Abboud C, Abboud D, Abdulrahman AO, Bondar AN, Dam J, Georgoussi Z, Giraldo J, Horvat A, Karoussiotis C, Paz-Castro A, Scarpa M, Schihada H, Scholz N, Güvenc Tuna B, Vardjan N. Birgül Iyison N, et al. Among authors: scarpa m. Br J Pharmacol. 2024 Jun 2. doi: 10.1111/bph.16389. Online ahead of print. Br J Pharmacol. 2024. PMID: 38825750 Review.