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FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.
Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Petković H. Goranovič D, et al. Among authors: martinez castro m. BMC Microbiol. 2012 Oct 19;12:238. doi: 10.1186/1471-2180-12-238. BMC Microbiol. 2012. PMID: 23083511 Free PMC article.
Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF. Barreiro C, et al. Among authors: martinez castro m. J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12. J Bacteriol. 2012. PMID: 22740677 Free PMC article.
The RNA polymerase omega factor RpoZ is regulated by PhoP and has an important role in antibiotic biosynthesis and morphological differentiation in Streptomyces coelicolor.
Santos-Beneit F, Barriuso-Iglesias M, Fernández-Martínez LT, Martínez-Castro M, Sola-Landa A, Rodríguez-García A, Martín JF. Santos-Beneit F, et al. Among authors: martinez castro m. Appl Environ Microbiol. 2011 Nov;77(21):7586-94. doi: 10.1128/AEM.00465-11. Epub 2011 Sep 9. Appl Environ Microbiol. 2011. PMID: 21908625 Free PMC article.
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