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Showing results for hirano hss
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Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.
Hirano I, Dellon ES, Hamilton JD, Collins MH, Peterson K, Chehade M, Schoepfer AM, Safroneeva E, Rothenberg ME, Falk GW, Assouline-Dayan Y, Zhao Q, Chen Z, Swanson BN, Pirozzi G, Mannent L, Graham NMH, Akinlade B, Stahl N, Yancopoulos GD, Radin A. Hirano I, et al. Gastroenterology. 2020 Jan;158(1):111-122.e10. doi: 10.1053/j.gastro.2019.09.042. Epub 2019 Oct 5. Gastroenterology. 2020. PMID: 31593702 Free article. Clinical Trial.

At week 12, dupilumab reduced the peak esophageal intraepithelial eosinophil count by a mean 86.8 eosinophils per high-power field (reduction of 107.1%; P < .0001 vs placebo), the EoE-histologic scoring system (HSS) severity score by 68.3% (P < .0001 vs placebo), and

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At week 12, dupilumab reduced the peak esophageal intraepithelial eosinophil count by a mean 86.8 eosinophils per high-power field (reductio …
Efficacy and safety of dupilumab up to 52 weeks in adults and adolescents with eosinophilic oesophagitis (LIBERTY EoE TREET study): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
Rothenberg ME, Dellon ES, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Sun X, Hamilton JD, Mortensen E, Laws E, Maloney J, Mannent LP, McCann E, Liu X, Glotfelty L, Shabbir A. Rothenberg ME, et al. Lancet Gastroenterol Hepatol. 2023 Nov;8(11):990-1004. doi: 10.1016/S2468-1253(23)00204-2. Epub 2023 Aug 31. Lancet Gastroenterol Hepatol. 2023. PMID: 37660704
At week 52, mean change from part B baseline in eosinophilic oesophagitis Histology Scoring System (HSS) grade score was -1.0 point (95% CI -1.1 to -0.9) in the weekly dupilumab/weekly dupilumab group and -0.9 points (-1.0 to -0.8) in the placebo/weekly dupilumab group; me …
At week 52, mean change from part B baseline in eosinophilic oesophagitis Histology Scoring System (HSS) grade score was -1.0 point ( …
Responsiveness of a Histologic Scoring System Compared With Peak Eosinophil Count in Eosinophilic Esophagitis.
Ma C, Jairath V, Feagan BG, Guizzetti L, Zou G, McFarlane SC, Shackelton LM, Collins MH, Hirano I, de Rooij WE, Schaeffer DF, Pai RK, Bredenoord AJ, Dellon ES. Ma C, et al. Am J Gastroenterol. 2022 Feb 1;117(2):264-271. doi: 10.14309/ajg.0000000000001571. Am J Gastroenterol. 2022. PMID: 34797816
We assessed the responsiveness of the EoE Histologic Scoring System (EoE-HSS) when compared with that of the peak eosinophil count (PEC). ...Two blinded gastrointestinal pathologists scored biopsies on the EoE-HSS, PEC, and 100-mm visual analog scale (VAS) of overal …
We assessed the responsiveness of the EoE Histologic Scoring System (EoE-HSS) when compared with that of the peak eosinophil count (P …
Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study.
Shoda T, Wen T, Aceves SS, Abonia JP, Atkins D, Bonis PA, Caldwell JM, Capocelli KE, Carpenter CL, Collins MH, Dellon ES, Eby MD, Gonsalves N, Gupta SK, Falk GW, Hirano I, Menard-Katcher P, Kuhl JT, Krischer JP, Leung J, Mukkada VA, Spergel JM, Trimarchi MP, Yang GY, Zimmermann N, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Shoda T, et al. Lancet Gastroenterol Hepatol. 2018 Jul;3(7):477-488. doi: 10.1016/S2468-1253(18)30096-7. Epub 2018 May 3. Lancet Gastroenterol Hepatol. 2018. PMID: 29730081 Free PMC article.
Histological and endoscopic features were assessed by quantification of oesophageal eosinophils and use of the eosinophilic oesophagitis histology scoring system (HSS) and the eosinophilic oesophagitis endoscopic reference score (EREFS). ...In the discovery cohort, EDP sho …
Histological and endoscopic features were assessed by quantification of oesophageal eosinophils and use of the eosinophilic oesophagitis his …
Budesonide Oral Suspension Significantly Improves Eosinophilic Esophagitis Histology Scoring System Results: Analyses From a 12-Week, Phase 2, Randomized, Placebo-controlled Trial.
Collins MH, Dellon ES, Katzka DA, Hirano I, Williams J, Lan L. Collins MH, et al. Am J Surg Pathol. 2019 Nov;43(11):1501-1509. doi: 10.1097/PAS.0000000000001361. Am J Surg Pathol. 2019. PMID: 31498177 Clinical Trial.
Change in EoE HSS stage total score correlated weakly with change in Dysphagia Symptom Questionnaire scores (grade: R=0.1925; P=0.0740; stage: R=0.2135; P=0.0471). These data demonstrate that the EoE HSS is a valuable endpoint of treatment response in randomized cli …
Change in EoE HSS stage total score correlated weakly with change in Dysphagia Symptom Questionnaire scores (grade: R=0.1925; P=0.074 …
The possible role of hematopoietic cell kinase in the pathophysiology of COPD.
Yanagisawa S, Sugiura H, Yokoyama T, Yamagata T, Ichikawa T, Akamatsu K, Koarai A, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M. Yanagisawa S, et al. Chest. 2009 Jan;135(1):94-101. doi: 10.1378/chest.07-3020. Epub 2008 Aug 21. Chest. 2009. PMID: 18719065
Peripheral blood neutrophils were isolated from 22 patients with COPD and 9 healthy subjects (HSs). The protein levels of Hck and phosphorylated Hck were assessed, and the correlation with various background characteristics was evaluated. RESULTS: The Hck protein level was …
Peripheral blood neutrophils were isolated from 22 patients with COPD and 9 healthy subjects (HSs). The protein levels of Hck and pho …
Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD.
Yamagata T, Sugiura H, Yokoyama T, Yanagisawa S, Ichikawa T, Ueshima K, Akamatsu K, Hirano T, Nakanishi M, Yamagata Y, Matsunaga K, Minakata Y, Ichinose M. Yamagata T, et al. Chest. 2007 Sep;132(3):890-9. doi: 10.1378/chest.07-0569. Epub 2007 Jun 15. Chest. 2007. PMID: 17573488

RESULTS: Both CD-11b and CXCR1 expression were significantly higher in COPD patients than in HSs (mean [+/- SE] CD-11b concentration: HSs, 9.7 +/- 1.0; COPD patients, 14.2 +/- 1.8 [p < 0.05]; mean CXCR1 concentration: HSs, 9.6 +/- 0.5; COPD patients, 11.9

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RESULTS: Both CD-11b and CXCR1 expression were significantly higher in COPD patients than in HSs (mean [+/- SE] CD-11b concentration: …
ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer.
Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H. Hashimoto S, et al. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17450-17459. doi: 10.1073/pnas.1901765116. Epub 2019 Aug 9. Proc Natl Acad Sci U S A. 2019. PMID: 31399545 Free PMC article.
I cannot remember, but I know my past events: remembering and knowing in a patient with amnesic syndrome.
Hirano M, Noguchi K, Hosokawa T, Takayama T. Hirano M, et al. J Clin Exp Neuropsychol. 2002 Jun;24(4):548-55. doi: 10.1076/jcen.24.4.548.1041. J Clin Exp Neuropsychol. 2002. PMID: 12187467
Case Y.K. has severe anterograde amnesia and a selective loss of specific personal episodes in his remote memories (Hirano & Noguchi, 1998). In this paper, we attempted to analyze remembering (R) and knowing (K) responses, that is, the relationship between autobiograph …
Case Y.K. has severe anterograde amnesia and a selective loss of specific personal episodes in his remote memories (Hirano & Nogu …
15 results