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Page 1
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.
Gay CM, Stewart CA, Park EM, Diao L, Groves SM, Heeke S, Nabet BY, Fujimoto J, Solis LM, Lu W, Xi Y, Cardnell RJ, Wang Q, Fabbri G, Cargill KR, Vokes NI, Ramkumar K, Zhang B, Della Corte CM, Robson P, Swisher SG, Roth JA, Glisson BS, Shames DS, Wistuba II, Wang J, Quaranta V, Minna J, Heymach JV, Byers LA. Gay CM, et al. Cancer Cell. 2021 Mar 8;39(3):346-360.e7. doi: 10.1016/j.ccell.2020.12.014. Epub 2021 Jan 21. Cancer Cell. 2021. PMID: 33482121 Free PMC article.
Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko Ł, Mazur PK, Gozani O. Yuan G, et al. Nature. 2021 Feb;590(7846):504-508. doi: 10.1038/s41586-020-03170-y. Epub 2021 Feb 3. Nature. 2021. PMID: 33536620 Free PMC article.
Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology.
Stewart CA, Gay CM, Ramkumar K, Cargill KR, Cardnell RJ, Nilsson MB, Heeke S, Park EM, Kundu ST, Diao L, Wang Q, Shen L, Xi Y, Zhang B, Della Corte CM, Fan Y, Kundu K, Gao B, Avila K, Pickering CR, Johnson FM, Zhang J, Kadara H, Minna JD, Gibbons DL, Wang J, Heymach JV, Byers LA. Stewart CA, et al. bioRxiv [Preprint]. 2021 Jan 28:2020.05.28.122291. doi: 10.1101/2020.05.28.122291. bioRxiv. 2021. PMID: 32577652 Free PMC article. Updated. Preprint.
Work-Related Exposures and Sickness Absence Trajectories: A Nationally Representative Follow-up Study among Finnish Working-Aged People.
Lallukka T, Kaila-Kangas L, Mänty M, Koskinen S, Haukka E, Kausto J, Leino-Arjas P, Kaikkonen R, Halonen JI, Shiri R. Lallukka T, et al. Int J Environ Res Public Health. 2019 Jun 13;16(12):2099. doi: 10.3390/ijerph16122099. Int J Environ Res Public Health. 2019. PMID: 31200553 Free PMC article.
The contribution of physically demanding work to the developmental trajectories of sickness absence (SA) has seldom been examined. We analyzed the associations of 12 physical work exposures, individually and in combination, with SA trajectories among the occupationa …
The contribution of physically demanding work to the developmental trajectories of sickness absence (SA) has seldom been examined. We …
Resistance to mutant KRASV12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line.
Muraki N, Yamada M, Doki H, Nakai R, Komeda K, Goto D, Kawabe N, Matsuoka K, Matsushima M, Kawabe T, Tanaka I, Morise M, Shay JW, Minna JD, Sato M. Muraki N, et al. Exp Cell Res. 2022 May 1;414(1):113053. doi: 10.1016/j.yexcr.2022.113053. Epub 2022 Feb 8. Exp Cell Res. 2022. PMID: 35149086 Free PMC article.
Upon mutant KRAS(V12) expression, only a small HBEC3-RIN2 cell subset underwent senescence, as assessed by a senescence-associated beta-galactosidase staining (SA-betaG) method. Furthermore, mutant KRAS(V12) enhanced cell growth, evaluated by colorimetric proliferation ass …
Upon mutant KRAS(V12) expression, only a small HBEC3-RIN2 cell subset underwent senescence, as assessed by a senescence-associated beta-gala …
Subjective cognitive complaints and permanent work disability: a prospective cohort study.
Pihlajamäki M, Arola H, Ahveninen H, Ollikainen J, Korhonen M, Nummi T, Uitti J, Taimela S. Pihlajamäki M, et al. Int Arch Occup Environ Health. 2021 Jul;94(5):901-910. doi: 10.1007/s00420-020-01643-1. Epub 2021 Jan 19. Int Arch Occup Environ Health. 2021. PMID: 33462663 Free PMC article.
We excluded employees who were on long-term sickness absence (SA) or had received a DB at baseline. The exposure variable was the presence of SCC. Age and SA before the questionnaire as a proxy measure of general health were treated as confounders and the analyses w …
We excluded employees who were on long-term sickness absence (SA) or had received a DB at baseline. The exposure variable was the pre …
Self-Certified Sickness Absence among Young Municipal Employees-Changes from 2002 to 2016 and Occupational Class Differences.
Sumanen H, Pietiläinen O, Mänty M. Sumanen H, et al. Int J Environ Res Public Health. 2017 Sep 26;14(10):1131. doi: 10.3390/ijerph14101131. Int J Environ Res Public Health. 2017. PMID: 28954443 Free PMC article.
Most of the trends first increased and turned to decrease in 2007/2010. Managers and professionals had the least amount of SA, but steadily increasing trends were observed among men. Self-certified SA followed only partially the typical socioeconomic gradient, as ro …
Most of the trends first increased and turned to decrease in 2007/2010. Managers and professionals had the least amount of SA, but st …
Effect of wet storage conditions on potato tuber transcriptome, phytohormones and growth.
Peivastegan B, Hadizadeh I, Nykyri J, Nielsen KL, Somervuo P, Sipari N, Tran C, Pirhonen M. Peivastegan B, et al. BMC Plant Biol. 2019 Jun 17;19(1):262. doi: 10.1186/s12870-019-1875-y. BMC Plant Biol. 2019. PMID: 31208336 Free PMC article.
Hormone measurements after incubation showed increased salicylic acid (SA), abscisic acid (ABA) and auxin (IAA) concentrations as well as reduced production of jasmonate 12-oxo-phytodienoic acid (OPDA) in wet tubers. ...CONCLUSIONS: In wet conditions, tubers invest in ROS …
Hormone measurements after incubation showed increased salicylic acid (SA), abscisic acid (ABA) and auxin (IAA) concentrations as wel …
The distinction of small cell and non-small cell lung cancer by growth in native-state histoculture.
Vescio RA, Connors KM, Bordin GM, Robb JA, Youngkin T, Umbreit JN, Hoffman RM. Vescio RA, et al. Cancer Res. 1990 Sep 15;50(18):6095-9. Cancer Res. 1990. PMID: 2168289
This distinction has significant impact therapeutically because of their relative difference in chemoresponsiveness (J.D. Minna et al., Principles and Practice of Oncology, pp. 396-474, 1981). ...
This distinction has significant impact therapeutically because of their relative difference in chemoresponsiveness (J.D. Minna et al …
First-in-human phase 1 study of budigalimab, an anti-PD-1 inhibitor, in patients with non-small cell lung cancer and head and neck squamous cell carcinoma.
Italiano A, Cassier PA, Lin CC, Alanko T, Peltola KJ, Gazzah A, Shiah HS, Calvo E, Cervantes A, Roda D, Tosi D, Gao B, Millward M, Warburton L, Tanner M, Englert S, Lambert S, Parikh A, Afar DE, Vosganian G, Moreno V. Italiano A, et al. Cancer Immunol Immunother. 2022 Feb;71(2):417-431. doi: 10.1007/s00262-021-02973-w. Epub 2021 Jul 3. Cancer Immunol Immunother. 2022. PMID: 34216247 Free PMC article. Clinical Trial.
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