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Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.
Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P. Kovarik Z, et al. Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7. Chem Biol Interact. 2013. PMID: 22960624 Free PMC article.
A directed library of thirty uncharged oximes that contain tertiary amine or imidazole protonable functional groups that should cross the BBB as unionized species was tested as tabun-hAChE conjugate reactivators along with three reference oximes: DAM (diacetylmonoxime), MINA
A directed library of thirty uncharged oximes that contain tertiary amine or imidazole protonable functional groups that should cross the BB …