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Aliskiren and losartan trial in non-diabetic chronic kidney disease.
Woo KT, Choong HL, Wong KS, Tan HK, Foo M, Fook-Chong S, Lee EJ, Anantharaman V, Lee GS, Chan CM. Woo KT, et al. J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):515-22. doi: 10.1177/1470320313510584. Epub 2014 Apr 17. J Renin Angiotensin Aldosterone Syst. 2014. PMID: 24742970 Free article. Clinical Trial.
MATERIALS AND METHODS: This was a randomised trial in 155 patients with non-diabetic CKD comparing aliskiren (150 mg/day) (n=52) versus losartan (100 mg/day) (n=52) and the third group aliskiren (150 mg/day) combined with losartan (100 mg/day) (n=51). The trial utilised primary r …
MATERIALS AND METHODS: This was a randomised trial in 155 patients with non-diabetic CKD comparing aliskiren (150 mg/day) (n=52) versus losa …
Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.
Jayaraman S, Lee L, Mata J, Droeser R, Kaneva P, Liberman S, Charlebois P, Stein B, Fried G, Feldman L, Schellenberg M, Inaba K, Cheng V, Bardes J, Lam L, Benjamin E, Matsushima K, Demetriades D, Schellenberg M, Inaba K, Cho J, Strumwasser A, Grabo D, Bir C, Eastman A, Demetriades D, Schellenberg M, Inaba K, Bardes J, Orozco N, Chen J, Park C, Kang T, Demetriades D, Jung J, Elfassy J, Grantcharov T, Jung J, Grantcharov T, Jung J, Grantcharov T, Taylor J, Stem M, Yu D, Chen S, Fang S, Gearhart S, Safar B, Efron J, Serrano P, Parpia S, McCarty D, Solis N, Valencia M, Jibrael S, Wei A, Gallinger S, Simunovic M, Hummadi A, Rabie M, Al Skaini M, Shamshad H, Shah S, Verhoeff K, Glen P, Taheri A, Min B, Tsang B, Fawcett V, Widder S, Yang M, Wanis K, Gilani O, Vogt K, Ott M, VanKoughnett J, Vinden C, Balvardi S, St Louis E, Yousef Y, Toobaie A, Guadagno E, Baird R, Poenaru D, Kleiman A, Mador B, Widder S, Serrano P, Moulton C, Lee E, Li C, Beyfuss K, Solomon H, Sela N, McAlister V, Ritter A, Gallinger S, Hallet J, Tsang M, Martel G, Jalink D, Husien M, Gu C, Levine M, Otiti S, Nginyangi J, Yeo C, Ring J, Holden M, Ungi T, Fichtinger G, Zevin B, Fang B, Dang J, Karmali S, Serrano P, Kim M,… See abstract for full author list ➔ Jayaraman S, et al. Can J Surg. 2018 Aug;61(4 Suppl 1):S94-S174. doi: 10.1503/cjs.010618. Epub 2018 Aug 1. Can J Surg. 2018. PMID: 35488393 Free PMC article. No abstract available.
Beneficial effects of high-dose losartan in IgA nephritis.
Woo KT, Chan CM, Tan HK, Choong HL, Foo M, Vathsala A, Lee EJ, Tan CC, Lee GS, Tan SH, Lim CH, Chiang GS, Fook-Chong S, Wong SK. Woo KT, et al. Clin Nephrol. 2009 Jun;71(6):617-24. doi: 10.5414/cnp71617. Clin Nephrol. 2009. PMID: 19473629 Clinical Trial.

RESULTS: Comparing patients on high-dose ARB (n = 63) with those on normal dose ARB (n = 43), normal dose ACEI (n = 61) and low-dose ACEI (n = 40), patients on high Dose ARB had significantly higher eGFR (p < 0.0005) and lower proteinuria (p < 0.005) at the end of the study

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RESULTS: Comparing patients on high-dose ARB (n = 63) with those on normal dose ARB (n = 43), normal dose ACEI (n = 61) and low-dose ACEI (n …
Effects of brief mindfulness and loving-kindness meditation inductions on emotional and behavioral responses to social rejection among individuals with high borderline personality traits.
Keng SL, Tan HH. Keng SL, et al. Behav Res Ther. 2018 Jan;100:44-53. doi: 10.1016/j.brat.2017.11.005. Epub 2017 Nov 22. Behav Res Ther. 2018. PMID: 29179024 Clinical Trial.
One hundred and eighteen participants were randomly assigned to receive 10 min of mindful breathing practice, LKM, or a no-instruction control condition, prior to exposure to a social rejection manipulation. ...
One hundred and eighteen participants were randomly assigned to receive 10 min of mindful breathing practice, LKM, or a no-instructio …
A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease.
Woo KT, Choong HL, Wong KS, Tan HK, Foo M, Stephanie FC, Lee EJ, Anantharaman V, Lee GS, Chan CM. Woo KT, et al. World J Nephrol. 2013 Nov 6;2(4):129-35. doi: 10.5527/wjn.v2.i4.129. World J Nephrol. 2013. PMID: 24255896 Free PMC article.

The study utilised primary renal end points of estimated Glomerular Filtration Rate (eGFR) < 15 mL/min or end stage renal failure. RESULTS: Patients treated with high dose ARB compared to the other two treatment groups had significantly less proteinuria at the end of 36

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The study utilised primary renal end points of estimated Glomerular Filtration Rate (eGFR) < 15 mL/min or end stage renal failure.

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High dose Losartan and ACE gene polymorphism in IgA nephritis.
Woo KT, Chan CM, Choong HL, Tan HK, Foo M, Lee EJ, Tan CC, Lee GS, Tan SH, Vathsala A, Lim CH, Chiang GS, Fook-Chong S, Yi Z, Tan HB, Wong KS. Woo KT, et al. Genomic Med. 2008 Dec;2(3-4):83-91. doi: 10.1007/s11568-009-9030-8. Epub 2009 Mar 25. Genomic Med. 2008. PMID: 19319668 Free PMC article.
Results Patients on high dose ARB had significantly lower proteinuria, 1.0 +/- 0.8 gm/day compared to 1.7 +/- 1.0 g/day in the other groups (P = 0.0005). The loss in eGFR was 0.7 ml min(-1)year(-1) for high dose ARB compared to 3.2-3.5 ml min(-1)year(-1) for the oth …
Results Patients on high dose ARB had significantly lower proteinuria, 1.0 +/- 0.8 gm/day compared to 1.7 +/- 1.0 g/day in the other groups …
Effects of brief mindful breathing and loving-kindness meditation on shame and social problem solving abilities among individuals with high borderline personality traits.
Keng SL, Tan JX. Keng SL, et al. Behav Res Ther. 2017 Oct;97:43-51. doi: 10.1016/j.brat.2017.07.004. Epub 2017 Jul 8. Behav Res Ther. 2017. PMID: 28710927 Clinical Trial.
Eighty-eight participants underwent a shame induction procedure involving recall of a negative autobiographical memory. They were then randomly assigned to 10 min of mindful breathing or LKM, or a no-instruction condition. ...
Eighty-eight participants underwent a shame induction procedure involving recall of a negative autobiographical memory. They were then rando …
Association between plasma soluble RAGE and renal function is unaffected by medication usage and enzymatic antioxidants in chronic kidney disease with type 2 diabetes.
Wong FN, Tan JA, Keng TC, Ng KP, Chua KH, Kuppusamy UR. Wong FN, et al. Clin Chim Acta. 2016 Jan 30;453:56-61. doi: 10.1016/j.cca.2015.12.002. Epub 2015 Dec 3. Clin Chim Acta. 2016. PMID: 26657980
METHODS: A total of 222 CKD patients whose eGFR is less than 60ml/min/1.73m(2) and 111 non-CKD individuals were recruited. The study subjects were classified based on their diabetes status. ...
METHODS: A total of 222 CKD patients whose eGFR is less than 60ml/min/1.73m(2) and 111 non-CKD individuals were recruited. The study …