Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Grocholski T, Dinis P, Niiranen L, Niemi J, Metsä-Ketelä M.
Grocholski T, et al.
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9866-71. doi: 10.1073/pnas.1501765112. Epub 2015 Jul 27.
Proc Natl Acad Sci U S A. 2015.
PMID: 26216966
Free PMC article.
The crystal structure of DnrK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution revealed that the inserted serine S297 resides in an alpha-helical segment adjacent to the substrate, but in a manner where the side chain points awa …
The crystal structure of DnrK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution revealed …