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Structure-based engineering of angucyclinone 6-ketoreductases.
Patrikainen P, Niiranen L, Thapa K, Paananen P, Tähtinen P, Mäntsälä P, Niemi J, Metsä-Ketelä M. Patrikainen P, et al. Chem Biol. 2014 Oct 23;21(10):1381-1391. doi: 10.1016/j.chembiol.2014.07.017. Epub 2014 Sep 4. Chem Biol. 2014. PMID: 25200607
Comparative Hepatic and Intestinal Efflux Transport of Statins.
Deng F, Tuomi SK, Neuvonen M, Hirvensalo P, Kulju S, Wenzel C, Oswald S, Filppula AM, Niemi M. Deng F, et al. Drug Metab Dispos. 2021 Sep;49(9):750-759. doi: 10.1124/dmd.121.000430. Epub 2021 Jun 23. Drug Metab Dispos. 2021. PMID: 34162690
Global analysis of genetic variation in SLCO1B1.
Pasanen MK, Neuvonen PJ, Niemi M. Pasanen MK, et al. Pharmacogenomics. 2008 Jan;9(1):19-33. doi: 10.2217/14622416.9.1.19. Pharmacogenomics. 2008. PMID: 18154446
Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Grocholski T, Dinis P, Niiranen L, Niemi J, Metsä-Ketelä M. Grocholski T, et al. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9866-71. doi: 10.1073/pnas.1501765112. Epub 2015 Jul 27. Proc Natl Acad Sci U S A. 2015. PMID: 26216966 Free PMC article.
The crystal structure of DnrK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution revealed that the inserted serine S297 resides in an alpha-helical segment adjacent to the substrate, but in a manner where the side chain points awa …
The crystal structure of DnrK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution revealed …
17 results