Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy.
Ong SB, Lee WH, Shao NY, Ismail NI, Katwadi K, Lim MM, Kwek XY, Michel NA, Li J, Newson J, Tahmasebi S, Rehman J, Kodo K, Jang HR, Ong SG.
Ong SB, et al.
Stem Cell Reports. 2019 Mar 5;12(3):597-610. doi: 10.1016/j.stemcr.2019.01.017. Epub 2019 Feb 21.
Stem Cell Reports. 2019.
PMID: 30799273
Free PMC article.
In addition, hyperglycemic iPSC-ECs had increased susceptibility to cell death when subjected to a secondary insult-simulated ischemia-reperfusion injury (sIRI). Importantly, calpain inhibition restored autophagy and reduced mitochondrial fragmentation, concurrent with mai …
In addition, hyperglycemic iPSC-ECs had increased susceptibility to cell death when subjected to a secondary insult-simulated ischemia-reper …