Microwave-assisted synthesis of substituted hexahydro-pyrrolo[3,2-c]quinolines

Michal Neuschl; Darek Bogdal; Milan Potacek

doi:10.3390/12010049

Microwave-assisted synthesis of substituted hexahydro-pyrrolo[3,2-c]quinolines

Molecules. 2007 Jan 24;12(1):49-59. doi: 10.3390/12010049.

Authors

Michal Neuschl¹, Darek Bogdal, Milan Potacek

Affiliation

¹ Department of Organic Chemistry, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Abstract

New compounds with the ethyl hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate skeleton were prepared by microwave-assisted intramolecular 1,3-dipolar cycloaddition reactions. The reactions were carried out under solvent-free conditions and compared with the same reaction in the presence of a solvent and a catalyst. Steric effects on the selectivity of the reaction were noted and evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Microwaves*
Models, Molecular
Molecular Structure
Pyrroles / chemistry*
Quinolines / chemical synthesis*
Quinolines / chemistry

Substances

Pyrroles
Quinolines
quinoline