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Bilirubin Binding to PPARα Inhibits Lipid Accumulation.
Stec DE, John K, Trabbic CJ, Luniwal A, Hankins MW, Baum J, Hinds TD Jr. Stec DE, et al. Among authors: hankins mw. PLoS One. 2016 Apr 12;11(4):e0153427. doi: 10.1371/journal.pone.0153427. eCollection 2016. PLoS One. 2016. PMID: 27071062 Free PMC article.
Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.
Hinds TD Jr, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. Hinds TD Jr, et al. Among authors: hankins mw. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E244-E252. doi: 10.1152/ajpendo.00396.2016. Epub 2017 Jan 17. Am J Physiol Endocrinol Metab. 2017. PMID: 28096081 Free PMC article.
Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.
Hinds TD Jr, Burns KA, Hosick PA, McBeth L, Nestor-Kalinoski A, Drummond HA, AlAmodi AA, Hankins MW, Vanden Heuvel JP, Stec DE. Hinds TD Jr, et al. Among authors: hankins mw. J Biol Chem. 2016 Nov 25;291(48):25179-25191. doi: 10.1074/jbc.M116.731703. Epub 2016 Oct 10. J Biol Chem. 2016. PMID: 27738106 Free PMC article.