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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex.
Vasta JD, Michaud A, Zimprich CA, Beck MT, Swiatnicki MR, Zegzouti H, Thomas MR, Wilkinson J, Crapster JA, Robers MB. Vasta JD, et al. Among authors: beck mt. Cell Chem Biol. 2023 Nov 16;30(11):1354-1365.e6. doi: 10.1016/j.chembiol.2023.07.019. Epub 2023 Aug 28. Cell Chem Biol. 2023. PMID: 37643616 Free article.
KRAS is vulnerable to reversible switch-II pocket engagement in cells.
Vasta JD, Peacock DM, Zheng Q, Walker JA, Zhang Z, Zimprich CA, Thomas MR, Beck MT, Binkowski BF, Corona CR, Robers MB, Shokat KM. Vasta JD, et al. Among authors: beck mt. Nat Chem Biol. 2022 Jun;18(6):596-604. doi: 10.1038/s41589-022-00985-w. Epub 2022 Mar 21. Nat Chem Biol. 2022. PMID: 35314814 Free PMC article.
DELs enable the development of BRET probes for target engagement studies in cells.
Teske KA, Su W, Corona CR, Wen J, Deng J, Ping Y, Zhang Z, Zhang Q, Wilkinson J, Beck MT, Nealey KR, Vasta JD, Cong M, Meisenheimer PL, Kuai L, Robers MB. Teske KA, et al. Among authors: beck mt. Cell Chem Biol. 2023 Aug 17;30(8):987-998.e24. doi: 10.1016/j.chembiol.2023.06.019. Epub 2023 Jul 24. Cell Chem Biol. 2023. PMID: 37490918 Free article.
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