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LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights.
Skelton PD, Tokars V, Parisiadou L. Skelton PD, et al. Cells. 2022 Jan 5;11(1):169. doi: 10.3390/cells11010169. Cells. 2022. PMID: 35011731 Free PMC article. Review.
It also highlights several LRRK2 effectors that could mediate the alterations to striatal function, including Rabs and protein kinase A. The lessons learned from improving our understanding of the pathogenic effects of LRRK2 mutations in striatal neurons will be applicable …
It also highlights several LRRK2 effectors that could mediate the alterations to striatal function, including Rabs and protein kinase …
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.
Wankel B, Ouyang J, Guo X, Hadjiolova K, Miller J, Liao Y, Tham DK, Romih R, Andrade LR, Gumper I, Simon JP, Sachdeva R, Tolmachova T, Seabra MC, Fukuda M, Schaeren-Wiemers N, Hong WJ, Sabatini DD, Wu XR, Kong X, Kreibich G, Rindler MJ, Sun TT. Wankel B, et al. Mol Biol Cell. 2016 May 15;27(10):1621-34. doi: 10.1091/mbc.E15-04-0230. Epub 2016 Mar 23. Mol Biol Cell. 2016. PMID: 27009205 Free PMC article.
These data support a unifying model in which UP cargoes are targeted for apical insertion via sequential interactions with Rabs and their effectors, SNAREs and MAL, and in which K20 plays a key role in regulating vesicular trafficking....
These data support a unifying model in which UP cargoes are targeted for apical insertion via sequential interactions with Rabs and t …
LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
Fais M, Sanna G, Galioto M, Nguyen TTD, Trần MUT, Sini P, Carta F, Turrini F, Xiong Y, Dawson TM, Dawson VL, Crosio C, Iaccarino C. Fais M, et al. Cells. 2021 Jan 20;10(2):203. doi: 10.3390/cells10020203. Cells. 2021. PMID: 33498474 Free PMC article.
The exocyst complex is an evolutionarily conserved multisubunit protein complex mainly involved in tethering secretory vesicles to the plasma membrane and implicated in the regulation of multiple biological processes modulated by vesicle trafficking. Interestingly, Rabs an …
The exocyst complex is an evolutionarily conserved multisubunit protein complex mainly involved in tethering secretory vesicles to the plasm …
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively.
Marchand A, Sarchione A, Athanasopoulos PS, Roy HB, Goveas L, Magnez R, Drouyer M, Emanuele M, Ho FY, Liberelle M, Melnyk P, Lebègue N, Thuru X, Nichols RJ, Greggio E, Kortholt A, Galli T, Chartier-Harlin MC, Taymans JM. Marchand A, et al. Cells. 2022 Mar 17;11(6):1018. doi: 10.3390/cells11061018. Cells. 2022. PMID: 35326469 Free PMC article.
Biochemical pathways mediated by KLK6 protease in breast cancer.
Pampalakis G, Zingkou E, Sidiropoulos KG, Diamandis EP, Zoumpourlis V, Yousef GM, Sotiropoulou G. Pampalakis G, et al. Mol Oncol. 2019 Nov;13(11):2329-2343. doi: 10.1002/1878-0261.12493. Epub 2019 Sep 30. Mol Oncol. 2019. PMID: 30980596 Free PMC article.
Overexpression of KLK6 is associated with increased metastatic ability of breast cancer cells into lungs, increased expression of certain S100 proteins (S100A4, S100A11) and keratins (KRT), and downregulation of the apoptosis-related proteases CASP7 and CASP8, and RABs. On …
Overexpression of KLK6 is associated with increased metastatic ability of breast cancer cells into lungs, increased expression of certain S1 …
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Steger M, et al. Elife. 2016 Jan 29;5:e12813. doi: 10.7554/eLife.12813. Elife. 2016. PMID: 26824392 Free PMC article.
Pathogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rabs and this strongly decreases their affinity to regulatory proteins including Rab GDP dissociation inhibitors (GDIs). Our findings uncover a key class of bona-fide LRRK2 substr …
Pathogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rabs and this strongly decreases their …
Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases.
Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Hyvola N, et al. EMBO J. 2006 Aug 23;25(16):3750-61. doi: 10.1038/sj.emboj.7601274. Epub 2006 Aug 10. EMBO J. 2006. PMID: 16902405 Free PMC article.
In vitro experiments demonstrate that rab5 and rab6 directly stimulate the 5-phosphatase activity of OCRL1. We conclude that rabs play a dual role in regulation of OCRL1, firstly targeting it to the Golgi apparatus and endosomes, and secondly, directly stimulating the 5-ph …
In vitro experiments demonstrate that rab5 and rab6 directly stimulate the 5-phosphatase activity of OCRL1. We conclude that rabs pla …