Effects of dietary benzo[a]pyrene on growth and hematological parameters in juvenile rockfish, Sebastes schlegeli (Hilgendorf)

Bull Environ Contam Toxicol. 2008 Nov;81(5):470-4. doi: 10.1007/s00128-008-9499-1. Epub 2008 Aug 2.

Abstract

Experiments were conducted to evaluate the effect of dietary benzo[a]pyrene (B[a]P) on the growth and hematological parameters of rockfish, Sebastes schlegeli, after they were fed with subchronic dietary B[a]P for 30 days. The weight growth rate of the rockfish was significantly different from that of the control group at dietary B[a]P concentration of 1.5 and 2.0 mg/kg. Significant reduction in red blood cells, hematocrit, and hemoglobin were observed during 30 days of exposure to the highest concentration. Over 30 days, serum AST increased at a B[a]P concentration of 1.5 mg/kg and LDH increased at a B[a]P concentration of 1.0 mg/kg concentration. However, no changes were observed in ALT, total protein, magnesium or calcium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Benzo(a)pyrene / toxicity*
  • Blood / drug effects*
  • Blood Cell Count
  • Blood Chemical Analysis
  • Diet*
  • Environmental Pollutants / toxicity*
  • Fishes / physiology*
  • Growth / drug effects*
  • Hematocrit
  • Hemoglobins / analysis
  • Hemoglobins / metabolism
  • L-Lactate Dehydrogenase / blood
  • Water Pollutants, Chemical / toxicity

Substances

  • Environmental Pollutants
  • Hemoglobins
  • Water Pollutants, Chemical
  • Benzo(a)pyrene
  • L-Lactate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase