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951 results

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Showing results for mendelian zhao
Search for Menglian Zhao instead (2 results)
Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study.
Long Y, Tang L, Zhou Y, Zhao S, Zhu H. Long Y, et al. BMC Med. 2023 Feb 21;21(1):66. doi: 10.1186/s12916-023-02761-6. BMC Med. 2023. PMID: 36810112 Free PMC article.
METHODS: We first identified two sets of gut microbiota based on phylum, class, order, family, and genus level information, and cancer data were obtained from the IEU Open GWAS project. We then performed two-sample Mendelian randomisation (MR) to determine whether the gut …
METHODS: We first identified two sets of gut microbiota based on phylum, class, order, family, and genus level information, and cancer data …
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S. Chen J, et al. EBioMedicine. 2023 Mar;89:104494. doi: 10.1016/j.ebiom.2023.104494. Epub 2023 Feb 27. EBioMedicine. 2023. PMID: 36857861 Free PMC article.
The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to identify possible targets for IBD. ...
The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization a …
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome.
Liu X, Tong X, Zou Y, Lin X, Zhao H, Tian L, Jie Z, Wang Q, Zhang Z, Lu H, Xiao L, Qiu X, Zi J, Wang R, Xu X, Yang H, Wang J, Zong Y, Liu W, Hou Y, Zhu S, Jia H, Zhang T. Liu X, et al. Nat Genet. 2022 Jan;54(1):52-61. doi: 10.1038/s41588-021-00968-y. Epub 2022 Jan 3. Nat Genet. 2022. PMID: 34980918
The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chinese individuals with whole-genome, whole-metagenome, anthropometri …
The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we per …
Mendelian randomization analyses for PCOS: evidence, opportunities, and challenges.
Wang C, Wu W, Yang H, Ye Z, Zhao Y, Liu J, Mu L. Wang C, et al. Trends Genet. 2022 May;38(5):468-482. doi: 10.1016/j.tig.2022.01.005. Epub 2022 Jan 31. Trends Genet. 2022. PMID: 35094873 Review.
Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through genetic variation, Mendelian randomization (MR) assesses causal associations between PCOS risk and related exposure factors. ...
Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through gene …
Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study.
Wang Y, Ye C, Kong L, Zheng J, Xu M, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Ning G, Bi Y, Wang T. Wang Y, et al. Hypertension. 2023 Jan;80(1):192-203. doi: 10.1161/HYPERTENSIONAHA.122.20286. Epub 2022 Nov 10. Hypertension. 2023. PMID: 36353998 Free PMC article.
METHODS: Using summary statistics of genome-wide association studies of predominantly European ancestry, we conducted 2-sample multivariable Mendelian randomization to estimate the independent effects of education, intelligence, or cognition on hypertension (FinnGen study, …
METHODS: Using summary statistics of genome-wide association studies of predominantly European ancestry, we conducted 2-sample multivariable …
Osteoporosis and sarcopenia-related traits: A bi-directional Mendelian randomization study.
Liu C, Liu N, Xia Y, Zhao Z, Xiao T, Li H. Liu C, et al. Front Endocrinol (Lausanne). 2022 Sep 14;13:975647. doi: 10.3389/fendo.2022.975647. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36187130 Free PMC article.
However, an observational study may be affected by potential confounders. Meanwhile, a Mendelian randomization (MR) study can overcome these confounders to assess causality. ...
However, an observational study may be affected by potential confounders. Meanwhile, a Mendelian randomization (MR) study can overcom …
Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study.
Ni JJ, Xu Q, Yan SS, Han BX, Zhang H, Wei XT, Feng GJ, Zhao M, Pei YF, Zhang L. Ni JJ, et al. Front Microbiol. 2022 Feb 4;12:737197. doi: 10.3389/fmicb.2021.737197. eCollection 2021. Front Microbiol. 2022. PMID: 35185808 Free PMC article.
Aiming to comprehensively investigate their causal relationship and to identify specific causal microbe taxa for psychiatric diseases, we conducted a two-sample Mendelian randomization (MR) analysis of gut microbiome with 15 psychiatric diseases. ...
Aiming to comprehensively investigate their causal relationship and to identify specific causal microbe taxa for psychiatric diseases, we co …
Association of Lipid-Lowering Drugs With Risk of Psoriasis: A Mendelian Randomization Study.
Zhao SS, Yiu ZZN, Barton A, Bowes J. Zhao SS, et al. JAMA Dermatol. 2023 Mar 1;159(3):275-280. doi: 10.1001/jamadermatol.2022.6051. JAMA Dermatol. 2023. PMID: 36696131 Free PMC article.
OBJECTIVE: To investigate the causal association between genetically proxied lipid-lowering drugs and psoriasis risk. DESIGN, SETTING, AND PARTICIPANTS: This 2-sample mendelian randomization study was performed from August to October 2022 and included population-level geno …
OBJECTIVE: To investigate the causal association between genetically proxied lipid-lowering drugs and psoriasis risk. DESIGN, SETTING, AND P …
Causal relationships between mood instability and autoimmune diseases: A mendelian randomization analysis.
Zhong H, Huan X, Jiao K, He S, Wen Z, Zhao R, Goh LY, Su M, Song J, Yan C, Xi J, Zheng X, Zhou Z, Luo S, Zhao C; Pan-Yangtze River Delta Alliance for Neuromuscular Disorders (PYDAN). Zhong H, et al. Autoimmun Rev. 2023 Jan;22(1):103214. doi: 10.1016/j.autrev.2022.103214. Epub 2022 Oct 20. Autoimmun Rev. 2023. PMID: 36272539
However, the causality between personality traits and autoimmune diseases remained largely unknown. METHODS: We first conducted two-sample mendelian randomization (MR) analysis on the relationships between mood instability, which is a common personality trait in the genera …
However, the causality between personality traits and autoimmune diseases remained largely unknown. METHODS: We first conducted two-sample …
Diabetes and intervertebral disc degeneration: A Mendelian randomization study.
Jin P, Xing Y, Xiao B, Wei Y, Yan K, Zhao J, Tian W. Jin P, et al. Front Endocrinol (Lausanne). 2023 Feb 28;14:1100874. doi: 10.3389/fendo.2023.1100874. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36926034 Free PMC article.
However, the causal relationship between these two common diseases remains unclear. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal association between T2DM and IVDD. ...
However, the causal relationship between these two common diseases remains unclear. METHODS: We conducted a two-sample Mendelian rand …
951 results