Abstract
To evaluate the effects of interferon beta-1a(INFbeta-1a) on brain metabolites in patients with multiple sclerosis (MS), we performed Magnetic Resonance Spectroscopy Imaging (MRSI) on five patients treated with INFbeta-1a (Rebif 44 microg), and on five untreated patients. Six healthy volunteers were used as controls. Patients were evaluated at the beginning, in the first, third, sixth, and twelfth month. There were no significant differences in normal appearing white matter (NAWM) metabolite peaks of the control group and patients with MS. However, in white matter lesions (WML) and NAWM there was significant differences between the basal and the other months' metabolic peaks (p < 0.05) in the treatment group although no differences emerged in the untreated group. These data suggest that INFbeta-1a has a favorable effect on restoration of metabolites in MS lesions.
Publication types
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Controlled Clinical Trial
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adult
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Aspartic Acid / analogs & derivatives
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Aspartic Acid / analysis
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Aspartic Acid / metabolism
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Biomarkers / analysis
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Biomarkers / metabolism
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Brain Mapping
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Central Nervous System / drug effects*
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Central Nervous System / metabolism
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Central Nervous System / pathology
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Choline / analysis
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Choline / metabolism
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Creatine / analysis
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Creatine / metabolism
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Disability Evaluation
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Female
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Humans
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Interferon beta-1a
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Interferon-beta / administration & dosage*
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Magnetic Resonance Spectroscopy / methods*
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Male
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Middle Aged
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Multiple Sclerosis / drug therapy*
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Multiple Sclerosis / metabolism
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Multiple Sclerosis / pathology
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Nerve Fibers, Myelinated / drug effects
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Nerve Fibers, Myelinated / metabolism
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Nerve Fibers, Myelinated / pathology
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Outcome Assessment, Health Care / methods
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Pilot Projects
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Treatment Outcome
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Young Adult
Substances
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Adjuvants, Immunologic
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Biomarkers
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Aspartic Acid
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Interferon-beta
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N-acetylaspartate
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Creatine
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Choline
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Interferon beta-1a