The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration

Melissa M Rowe; Klaus H Kaestner

doi:10.3390/cells12030359

The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration

Cells. 2023 Jan 18;12(3):359. doi: 10.3390/cells12030359.

Authors

Melissa M Rowe¹, Klaus H Kaestner¹

Affiliation

¹ Department of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania, Philadelphia, PA 19014, USA.

Abstract

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in liver disease and regeneration. Greater attention is given to more prevalent and well characterized RNAs, including: miR-122, miR-21, the let-7 family of miRs, miR-451a, miR-144, and MALAT1.

Keywords: circular RNA; liver disease; liver regeneration; long non-coding RNA; microRNA; non-coding RNA.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Humans
Liver Diseases* / genetics
MicroRNAs* / genetics
RNA, Circular / genetics
RNA, Long Noncoding* / genetics

Substances

MicroRNAs
RNA, Long Noncoding
RNA, Circular

Grants and funding

R01 CA249929/CA/NCI NIH HHS/United States