Heliotropium sclerocarpum Phil. (Heliotropiaceae) is a resinous bush that grows in the Atacama of northern Chile. The chemical composition of its resinous exudate was analyzed for the first time. One aromatic geranyl derivative: filifolinol (1), one flavanone: naringenin (2) and a new type of 3-oxo-2-arylbenzofuran derivative 3 were isolated and their structures were determined. The antioxidant activity of the phenolic compounds and resin was evaluated using the bleaching of DPPH radical method and expressed as fast reacting equivalents (FRE) and total reacting equivalents (TRE).